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dc.creatorKoehler, Niklas K. U.-
dc.creatorStransky, Elle-
dc.creatorMeyer, Mirjam-
dc.creatorGaertner, Susanne-
dc.creatorShing, Mona-
dc.creatorSchnaidt, Martina-
dc.creatorCelej, Maria Soledad-
dc.creatorJovin, Thomas M.-
dc.creatorLeyhe, Thomas-
dc.creatorLaske, Christoph-
dc.creatorBatra, Anil-
dc.creatorBuchkremer, Gerhard-
dc.creatorFallgatter, Andreas J.-
dc.creatorWernet, Dorothee-
dc.creatorRichartz Salzburger, Elke-
dc.date2016-12-29T21:19:30Z-
dc.date2016-12-29T21:19:30Z-
dc.date2015-04-
dc.date2016-12-28T17:54:42Z-
dc.date.accessioned2019-04-29T15:26:51Z-
dc.date.available2019-04-29T15:26:51Z-
dc.date.issued2015-04-
dc.identifierKoehler, Niklas K. U.; Stransky, Elle; Meyer, Mirjam; Gaertner, Susanne; Shing, Mona; et al.; Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging; Public Library of Science; Plos One; 10; 4; 4-2015; 1-16-
dc.identifier1932-6203-
dc.identifierhttp://hdl.handle.net/11336/10653-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294320-
dc.descriptionThere is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitive impairment and alpha-synuclein is being explored as a biomarker in CSF, blood serum and plasma. Considering key events of aging that include proteostasis, alpha-synuclein may not only be useful as a marker for differential diagnosis but also for aging per se. To explore this hypothesis, we developed a highly specific ELISA to measure alpha-synuclein. In healthy males plasma alpha-synuclein levels correlated strongly with age, revealing much lower concentrations in older (avg. 58.1 years) compared to younger (avg. 27.6 years) individuals. This difference between the age groups was enhanced after acidification of the plasmas (p<0.0001), possibly reflecting a decrease of alpha-synuclein-antibody complexes or chaperone activity in older individuals. Our results support the concept that alpha-synuclein homeostasis may be impaired early on, possibly due to disturbance of the proteostasis network, a key component of healthy aging. Thus, alpha-synuclein may be a novel biomarker of aging, a factor that should be considered when analyzing its presence in biological specimens.-
dc.descriptionFil: Koehler, Niklas K. U.. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. German Center for Neurodegenerative Diseases; Alemania-
dc.descriptionFil: Stransky, Elle. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania-
dc.descriptionFil: Meyer, Mirjam. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania-
dc.descriptionFil: Gaertner, Susanne. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania-
dc.descriptionFil: Shing, Mona. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania-
dc.descriptionFil: Schnaidt, Martina. Zentrum für Klinische Transfusionsmedizin; Alemania-
dc.descriptionFil: Celej, Maria Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Quimica Biológica; Argentina. Institute for Biophysical Chemistry. Laboratory for Cellular Dynamics, Max-Planck; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba (p); Argentina-
dc.descriptionFil: Jovin, Thomas M.. Institute for Biophysical Chemistry. Laboratory for Cellular Dynamics, Max-Planck; Alemania-
dc.descriptionFil: Leyhe, Thomas. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. Psychiatric University Hospital. Center of Old Age Psychiatry; Alemania-
dc.descriptionFil: Laske, Christoph . Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. German Center for Neurodegenerative Diseases; Alemania-
dc.descriptionFil: Batra, Anil. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania-
dc.descriptionFil: Buchkremer, Gerhard. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania-
dc.descriptionFil: Fallgatter, Andreas J.. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania-
dc.descriptionFil: Wernet, Dorothee. Zentrum für Klinische Transfusionsmedizin; Alemania-
dc.descriptionFil: Richartz Salzburger, Elke. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherPublic Library of Science-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123444-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0123444-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectALPHA-SYNUCLEIN-
dc.subjectPARKINSON-
dc.subjectBLOOD PLASMA-
dc.subjectBIOMARKER-
dc.subjectNeurociencias-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleAlpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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