Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Jacobo, Patricia Verónica | - |
| dc.creator | Guazzone, Vanesa Anabella | - |
| dc.creator | Pérez, Cecilia Valeria | - |
| dc.creator | Lustig, Livia | - |
| dc.date | 2017-04-12T20:30:45Z | - |
| dc.date | 2017-04-12T20:30:45Z | - |
| dc.date | 2015-02 | - |
| dc.date | 2017-04-07T14:28:16Z | - |
| dc.date.accessioned | 2019-04-29T15:27:00Z | - |
| dc.date.available | 2019-04-29T15:27:00Z | - |
| dc.date.issued | 2017-04-12T20:30:45Z | - |
| dc.date.issued | 2017-04-12T20:30:45Z | - |
| dc.date.issued | 2015-02 | - |
| dc.date.issued | 2017-04-07T14:28:16Z | - |
| dc.identifier | Jacobo, Patricia Verónica; Guazzone, Vanesa Anabella; Pérez, Cecilia Valeria; Lustig, Livia; CD4+ Foxp3+ Regulatory T cells in autoimmune orchitis: phenotypic and functional characterization.; Wiley; American Journal Of Reproductive Immunology; 73; 2; 2-2015; 109-125 | - |
| dc.identifier | 1046-7408 | - |
| dc.identifier | http://hdl.handle.net/11336/15260 | - |
| dc.identifier | 1600-0897 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294359 | - |
| dc.description | Problem: The phenotype and function of regulatory T (Treg) cells in rats with experimental autoimmune orchitis (EAO) was evaluated. Method of study: Distribution of Treg cells in draining lymph nodes from the testis (TLN) and from the site of immunization (ILN) was analysed by immunohistochemistry. The number, phenotype and proliferative response (5-bromo-2′-deoxyuridine incorporation) of Treg cells were evaluated by flow cytometry and Treg cell suppressive activity by in vitro experiments. TGF-β expression was evaluated by immunofluorescence. Results: Absolute numbers of Treg cells and BrdU+ Treg cells were increased in LN from experimental compared to normal and control rats. These cells displayed a CD45RC−, CD62L−, Helios+ phenotype. CD4+ CD25bright T cells from TLN of experimental rats were able to suppress T cell-proliferation more efficiently than those derived from normal and control rats. Cells isolated from TLN and ILN expressed TGF-β. Conclusion: Our results suggest that Treg cells with a memory/activated phenotype proliferate extensively in the inflamed testis and LN of rats with EAO exhibiting an enhanced suppressive capacity. TGF-β may be involved in their suppressive mechanism. | - |
| dc.description | Fil: Jacobo, Patricia Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.description | Fil: Guazzone, Vanesa Anabella. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.description | Fil: Pérez, Cecilia Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.description | Fil: Lustig, Livia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/aji.12312 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/aji.12312/abstract | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/15260 | - |
| dc.subject | IMMUNOREGULATION | - |
| dc.subject | INFLAMMATION | - |
| dc.subject | TESTIS | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | CD4+ Foxp3+ Regulatory T cells in autoimmune orchitis: phenotypic and functional characterization. | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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