Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Sánchez Miguel, Ignacio Enrique | - |
| dc.creator | Ferreiro, Diego | - |
| dc.creator | Dellarole, Mariano | - |
| dc.creator | de Prat Gay, Gonzalo | - |
| dc.date | 2017-04-12T14:16:01Z | - |
| dc.date | 2017-04-12T14:16:01Z | - |
| dc.date | 2010-04 | - |
| dc.date | 2017-03-29T14:46:10Z | - |
| dc.date.accessioned | 2019-04-29T15:27:11Z | - |
| dc.date.available | 2019-04-29T15:27:11Z | - |
| dc.date.issued | 2017-04-12T14:16:01Z | - |
| dc.date.issued | 2017-04-12T14:16:01Z | - |
| dc.date.issued | 2010-04 | - |
| dc.date.issued | 2017-03-29T14:46:10Z | - |
| dc.identifier | Sánchez Miguel, Ignacio Enrique; Ferreiro, Diego; Dellarole, Mariano; de Prat Gay, Gonzalo; Experimental snapshots of a protein-DNA binding landscape; National Academy of Sciences; Proceedings Of The National Academy Of Sciences Of The United States Of America; 107; 17; 4-2010; 7751-7756 | - |
| dc.identifier | http://hdl.handle.net/11336/15203 | - |
| dc.identifier | 1091-6490 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294414 | - |
| dc.description | Protein recognition of DNA sites is a primary event for gene function. Its ultimate mechanistic understanding requires an integrated structural, dynamic, kinetic, and thermodynamic dissection that is currently limited considering the hundreds of structures of protein-DNA complexes available. We describe a protein-DNA-binding pathway in which an initial, diffuse, transition state ensemble with some nonnative contacts is followed by formation of extensive nonnative interactions that drive the system into a kinetic trap. Finally, nonnative contacts are slowly rearranged into native-like interactions with the DNA backbone. Dissimilar protein-DNA interfaces that populate along the DNA-binding route are explained by a temporary degeneracy of protein-DNA interactions, centered on "dual-role" residues. The nonnative species slow down the reaction allowing for extended functionality. | - |
| dc.description | Fil: Sánchez Miguel, Ignacio Enrique. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina | - |
| dc.description | Fil: Ferreiro, Diego. Universidad Nacional de Quilmes; Argentina. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina | - |
| dc.description | Fil: Dellarole, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina | - |
| dc.description | Fil: de Prat Gay, Gonzalo. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | National Academy of Sciences | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/107/17/7751.long | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1073/pnas.0911734107 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/15203 | - |
| dc.subject | energy landscape | - |
| dc.subject | human papillomavirus E2 protein | - |
| dc.subject | kinetic trap | - |
| dc.subject | protein-DNA interaction | - |
| dc.subject | Biofísica | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Experimental snapshots of a protein-DNA binding landscape | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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