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dc.creatorGold, Marielle C.-
dc.creatorMcLaren, James E.-
dc.creatorReistetter, Joseph A.-
dc.creatorSmyk Pearson, Sue-
dc.creatorLadell, Kristin-
dc.creatorSwarbrick, Gwendolyn M.-
dc.creatorYu, Yik Y. L.-
dc.creatorHansen, Ted H.-
dc.creatorLund, Ole-
dc.creatorNielsen, Morten-
dc.creatorGerritsen, Bram-
dc.creatorKesmir, Can-
dc.creatorMiles, John J.-
dc.creatorLewinsohn, Deborah A.-
dc.creatorPrice, David A.-
dc.creatorLewinsohn, David M.-
dc.date2017-06-13T16:52:11Z-
dc.date2017-06-13T16:52:11Z-
dc.date2014-07-
dc.date2017-06-09T15:01:04Z-
dc.date.accessioned2019-04-29T15:27:15Z-
dc.date.available2019-04-29T15:27:15Z-
dc.date.issued2017-06-13T16:52:11Z-
dc.date.issued2017-06-13T16:52:11Z-
dc.date.issued2014-07-
dc.date.issued2017-06-09T15:01:04Z-
dc.identifierGold, Marielle C.; McLaren, James E.; Reistetter, Joseph A.; Smyk Pearson, Sue; Ladell, Kristin; et al.; MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage; Rockefeller Univ Press; Journal Of Experimental Medicine; 211; 8; 7-2014; 1601-1610-
dc.identifier0022-1007-
dc.identifierhttp://hdl.handle.net/11336/18089-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294440-
dc.descriptionMucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR) that detects microbial metabolites presented by the nonpolymorphic major histocompatibility complex (MHC)–like molecule MR1. The highly conserved nature of MR1 in conjunction with biased MAIT TCRα chain usage is widely thought to indicate limited ligand presentation and discrimination within a pattern-like recognition system. Here, we evaluated the TCR repertoire of MAIT cells responsive to three classes of microbes. Substantial diversity and heterogeneity were apparent across the functional MAIT cell repertoire as a whole, especially for TCRβ chain sequences. Moreover, different pathogen-specific responses were characterized by distinct TCR usage, both between and within individuals, suggesting that MAIT cell adaptation was a direct consequence of exposure to various exogenous MR1-restricted epitopes. In line with this interpretation, MAIT cell clones with distinct TCRs responded differentially to a riboflavin metabolite. These results suggest that MAIT cells can discriminate between pathogen-derived ligands in a clonotype-dependent manner, providing a basis for adaptive memory via recruitment of specific repertoires shaped by microbial exposure.-
dc.descriptionFil: Gold, Marielle C.. Oregon Health & Science University; Estados Unidos-
dc.descriptionFil: McLaren, James E.. Cardiff University; Reino Unido-
dc.descriptionFil: Reistetter, Joseph A.. Oregon Health & Science University; Estados Unidos-
dc.descriptionFil: Smyk Pearson, Sue. Oregon Health & Science University; Estados Unidos-
dc.descriptionFil: Ladell, Kristin. Cardiff University; Reino Unido-
dc.descriptionFil: Swarbrick, Gwendolyn M.. Oregon Health & Science University; Estados Unidos-
dc.descriptionFil: Yu, Yik Y. L.. Washington University in St. Louis; Estados Unidos-
dc.descriptionFil: Hansen, Ted H.. Washington University in St. Louis; Estados Unidos-
dc.descriptionFil: Lund, Ole. Technical University of Denmark; Dinamarca-
dc.descriptionFil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina-
dc.descriptionFil: Gerritsen, Bram. Utrecht Univeristy; Países Bajos-
dc.descriptionFil: Kesmir, Can. Utrecht Univeristy; Países Bajos-
dc.descriptionFil: Miles, John J.. Cardiff University; Reino Unido-
dc.descriptionFil: Lewinsohn, Deborah A.. Oregon Health & Science University; Estados Unidos-
dc.descriptionFil: Price, David A.. Cardiff University; Reino Unido. National Institutes of Health; Estados Unidos-
dc.descriptionFil: Lewinsohn, David M.. Oregon Health & Science University; Estados Unidos-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherRockefeller Univ Press-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://jem.rupress.org/content/211/8/1601.long-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1084/jem.20140507-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113934/-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectMAIT-
dc.subjectT cell-
dc.subjectT cell receptor-
dc.subjectOtras Ciencias de la Salud-
dc.subjectCiencias de la Salud-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleMR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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