Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Taylor, Jackson | - |
| dc.creator | Pereyra, Andrea Soledad | - |
| dc.creator | Zhang, Tan | - |
| dc.creator | Messi, Maria Laura | - |
| dc.creator | Wang, Zhong-Min | - |
| dc.creator | Hereñú, Claudia Beatriz | - |
| dc.creator | Kuan, Pei-Fen | - |
| dc.creator | Delbono, Osvaldo | - |
| dc.date | 2018-01-15T15:03:20Z | - |
| dc.date | 2018-01-15T15:03:20Z | - |
| dc.date | 2014-06 | - |
| dc.date | 2018-01-12T16:19:30Z | - |
| dc.date.accessioned | 2019-04-29T15:27:19Z | - |
| dc.date.available | 2019-04-29T15:27:19Z | - |
| dc.date.issued | 2018-01-15T15:03:20Z | - |
| dc.date.issued | 2018-01-15T15:03:20Z | - |
| dc.date.issued | 2014-06 | - |
| dc.date.issued | 2018-01-12T16:19:30Z | - |
| dc.identifier | Delbono, Osvaldo; Pereyra, Andrea Soledad; Zhang, Tan; Messi, Maria Laura; Hereñú, Claudia Beatriz; Taylor, Jackson; et al.; The Cavβ1a subunit regulates gene expression and suppresses myogenin in muscle progenitor cells; Rockefeller Univ Press; Journal Of Cell Biology; 205; 6; 6-2014; 829-846 | - |
| dc.identifier | 0021-9525 | - |
| dc.identifier | http://hdl.handle.net/11336/33227 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294462 | - |
| dc.description | Voltage-gated calcium channel (Cav) subunits are auxiliary subunits to Cavs. Recent reports show Cavsubunits may enter the nucleus and suggest a role in transcriptional regulation, but the physiological rele-vance of this localization remains unclear. We sought to define the nuclear function of Cav in muscle progenitor cells (MPCs). We found that Cav1a is expressed in prolif-erating MPCs, before expression of the calcium conduct-ing subunit Cav1.1, and enters the nucleus. Loss of Cav1aexpression impaired MPC expansion in vitro and in vivo and caused widespread changes in global gene expres-sion, including up-regulation of myogenin. Additionally, we found that Cav1a localizes to the promoter region of a number of genes, preferentially at noncanonical (NC) E-box sites. Cav1a binds to a region of the Myog promoter con-taining an NC E-box, suggesting a mechanism for inhibi-tion of myogenin gene expression. This work indicates that Cav1a acts as a Cav-independent regulator of gene ex-pression in MPCs, and is required for their normal expan-sion during myogenic development | - |
| dc.description | Fil: Taylor, Jackson. Wake Forest School of Medicine. Carolina del Norte; Estados Unidos | - |
| dc.description | Fil: Pereyra, Andrea Soledad. Wake Forest School of Medicine. Carolina del Norte; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina | - |
| dc.description | Fil: Zhang, Tan. Wake Forest School of Medicine. Carolina del Norte; Estados Unidos | - |
| dc.description | Fil: Messi, Maria Laura. Wake Forest School of Medicine. Carolina del Norte; Estados Unidos | - |
| dc.description | Fil: Wang, Zhong-Min. Wake Forest School of Medicine. Carolina del Norte; Estados Unidos | - |
| dc.description | Fil: Hereñú, Claudia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina | - |
| dc.description | Fil: Kuan, Pei-Fen. Stony Brook University. Stony Brook; Estados Unidos | - |
| dc.description | Fil: Delbono, Osvaldo. Wake Forest School of Medicine. Carolina del Norte; Estados Unidos | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Rockefeller Univ Press | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://jcb.rupress.org/content/205/6/829 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1083/jcb.201403021 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | CALCIUM CHANNEL BETA 1A SUBUNIT | - |
| dc.subject | MUSCLE PROGENITOR CELLS | - |
| dc.subject | GENE EXPRESSION | - |
| dc.subject | MYOGENIN | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | The Cavβ1a subunit regulates gene expression and suppresses myogenin in muscle progenitor cells | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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