Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Ambrosi, Nella Gabriela | - |
| dc.creator | Guerrieri, Diego | - |
| dc.creator | Caro, Fiorella Yanina | - |
| dc.creator | Barbieri Kennedy, Micaela | - |
| dc.creator | Sanchez, Francisco | - |
| dc.creator | Sanchez, Mercedes Leonor | - |
| dc.creator | Chuluyan, Hector Eduardo | - |
| dc.date | 2017-03-20T19:21:18Z | - |
| dc.date | 2017-03-20T19:21:18Z | - |
| dc.date | 2015-08 | - |
| dc.date | 2017-03-06T17:17:42Z | - |
| dc.date.accessioned | 2019-04-29T15:27:20Z | - |
| dc.date.available | 2019-04-29T15:27:20Z | - |
| dc.date.issued | 2017-03-20T19:21:18Z | - |
| dc.date.issued | 2017-03-20T19:21:18Z | - |
| dc.date.issued | 2015-08 | - |
| dc.date.issued | 2017-03-06T17:17:42Z | - |
| dc.identifier | Ambrosi, Nella Gabriela; Guerrieri, Diego; Caro, Fiorella Yanina; Barbieri Kennedy, Micaela ; Sanchez, Francisco; et al.; SLPI (secretory leukocyte peptidase inhibitor); University Hospital of Poitiers; Atlas of Genetics and Cytogenetics in Oncology and Haematology; 8-2015 | - |
| dc.identifier | 1768-3262 | - |
| dc.identifier | http://hdl.handle.net/11336/14112 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294472 | - |
| dc.description | Secretory Leukocyte Peptidase Inhibitor (SLPI) functionality in health and disease: Secretory Leukocyte Peptidase Inhibitor (SLPI) is a serine protease inhibitor of cathepsin G, trypsin and chymotrypsin, but primarily against neutrophil elastase. Its major function is to inhibit inflammation by blocking the proteolytic activity of these proteinases released by leukocytes and also through down-modulation of several cytokines. The anti-inflammatory activity is also mediated by inhibition of the activation of the transcription nuclear factor NF-kB. Some studies localized the molecule within the cytosol and in secondary granules of neutrophils. Because of this, it is believed that neutrophil-derived SLPI may regulate the protease/antiprotease balance at sites of tissue inflammation. In relation with the adaptive immune system, it was suggested that SLPI modulates the cellular and humoral immune response, by decreasing the T cell proliferation and reducing the class switching. Also, it is known that this polycationic non-glycosylated peptide, displays anti-microbial properties against bacteria, viruses (in particular HIV) and fungus. In summary, the SLPI is a pleitropic molecule, implicated in physiological and pathological events, such as wound healing, pregnancy, chronic obstructive pulmonary disease, cancer, ischemia reperfusion injury and stroke, among others. Their detection in serum and biological fluids may be useful as a biomarker to diagnosis and prognosis for certain diseases. | - |
| dc.description | Fil: Ambrosi, Nella Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.description | Fil: Guerrieri, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.description | Fil: Caro, Fiorella Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.description | Fil: Barbieri Kennedy, Micaela . Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.description | Fil: Sanchez, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.description | Fil: Sanchez, Mercedes Leonor. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.description | Fil: Chuluyan, Hector Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/vnd.openxmlformats-officedocument.wordprocessingml.document | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | University Hospital of Poitiers | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://atlasgeneticsoncology.org/Genes/SLPIID46048ch20q13.html | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | SLPI | - |
| dc.subject | ANTIMICROBIAL ACTIVITY | - |
| dc.subject | ANTI INFLAMMATORY ACTIVITY | - |
| dc.subject | ANTI TUMORAL ACTIVITY | - |
| dc.subject | Biología Celular, Microbiología | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | SLPI (secretory leukocyte peptidase inhibitor) | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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