Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Wargon, Victoria | - |
| dc.creator | Helguero, Luisa | - |
| dc.creator | Bolado, Julieta | - |
| dc.creator | Rojas, Paola Andrea | - |
| dc.creator | Novaro, Virginia | - |
| dc.creator | Molinolo, Alfredo | - |
| dc.creator | Lanari, Claudia Lee Malvina | - |
| dc.date | 2017-09-18T19:35:08Z | - |
| dc.date | 2017-09-18T19:35:08Z | - |
| dc.date | 2008-08 | - |
| dc.date | 2017-09-13T16:15:53Z | - |
| dc.date.accessioned | 2019-04-29T15:27:34Z | - |
| dc.date.available | 2019-04-29T15:27:34Z | - |
| dc.date.issued | 2017-09-18T19:35:08Z | - |
| dc.date.issued | 2017-09-18T19:35:08Z | - |
| dc.date.issued | 2008-08 | - |
| dc.date.issued | 2017-09-13T16:15:53Z | - |
| dc.identifier | Wargon, Victoria; Helguero, Luisa; Bolado, Julieta; Rojas, Paola Andrea; Novaro, Virginia; et al.; Reversal of antiprogestin resistance and progesterone receptor isoform ratio in acquired resistant mammary carcinomas; Springer; Breast Cancer Research and Treatment; 116; 3; 8-2008; 449-460 | - |
| dc.identifier | 0167-6806 | - |
| dc.identifier | http://hdl.handle.net/11336/24513 | - |
| dc.identifier | 1573-7217 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294533 | - |
| dc.description | To explore mechanisms related to hormone resistance, three resistant variants of the MPA mouse breast cancer tumor model with low levels of progesterone receptor (PR) isoform A (PR-A)/high PR-B expression were developed by prolonged selective pressure with antiprogestins. The resistant phenotype of one tumor line was reversed spontaneously after several consecutive passages in syngeneic BALB/c mice or by 17-beta-estradiol or tamoxifen treatment, and this reversion was significantly associated with an increase in PR-A expression. The responsive parental tumors disclosed low activation of ERK and high activation of AKT; resistant tumors on the other hand, showed the opposite, and this was associated with a higher metastatic potential, that did not revert. This study shows for the first time in vivo a relationship between PR isoform expression and antiprogestin responsiveness, demonstrating that, whereas acquired resistance may be reversed, changes in kinase activation and metastatic potential are unidirectional associated with tumor progression. | - |
| dc.description | Fil: Wargon, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Helguero, Luisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Karolinska Institutet; Suecia | - |
| dc.description | Fil: Bolado, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Rojas, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Novaro, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.description | Fil: Molinolo, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. National Institutes of Health; Estados Unidos | - |
| dc.description | Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Springer | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10549-008-0150-y | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s10549-008-0150-y | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | BREAST CANCER | - |
| dc.subject | HORMONE RESISTANCE | - |
| dc.subject | PROGESTERONE RECEPTORS | - |
| dc.subject | ANTIPROGESTINS | - |
| dc.subject | Patología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Reversal of antiprogestin resistance and progesterone receptor isoform ratio in acquired resistant mammary carcinomas | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.