Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Alvarez, María Soledad | - |
| dc.creator | Fernández Alvarez, Ana Julia | - |
| dc.creator | Cucarella, Carme | - |
| dc.creator | Casado Pinna, Marta | - |
| dc.date | 2017-01-10T18:03:04Z | - |
| dc.date | 2017-01-10T18:03:04Z | - |
| dc.date | 2014-04 | - |
| dc.date | 2016-11-18T15:20:10Z | - |
| dc.date.accessioned | 2019-04-29T15:27:40Z | - |
| dc.date.available | 2019-04-29T15:27:40Z | - |
| dc.date.issued | 2017-01-10T18:03:04Z | - |
| dc.date.issued | 2017-01-10T18:03:04Z | - |
| dc.date.issued | 2014-04 | - |
| dc.date.issued | 2016-11-18T15:20:10Z | - |
| dc.identifier | Alvarez, María Soledad; Fernández Alvarez, Ana Julia; Cucarella, Carme; Casado Pinna, Marta; Stable SREBP-1a knockdown decreases the cell proliferation rate in human preadipocyte cells without inducing senescence; Elsevier; Biochemical And Biophysical Research Communications; 447; 1; 4-2014; 51-56 | - |
| dc.identifier | 0006-291X | - |
| dc.identifier | http://hdl.handle.net/11336/11035 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294566 | - |
| dc.description | Sterol regulatory element binding proteins (SREBP), encoded by the Srebf1 and Srebf2 genes, are important regulators of genes involved in cholesterol and fatty acid metabolism. Whereas SREBP-2 controls the cholesterol synthesis, SREBP-1 proteins (-1a and -1c) function as the central hubs in lipid metabolism. Despite the key function of these transcription factors to promote adipocyte differentiation, the roles of SREBP-1 proteins during the preadipocyte state remain unknown. Here, we evaluate the role of SREBP-1 in preadipocyte proliferation using RNA interference technology. Knockdown of the SREBP-1a gene decreased the proliferation rate in human SGBS preadipocyte cell strain without inducing senescence. Furthermore, our data identified retinoblastoma binding protein 8 and cyclin-dependent kinase inhibitor 3 genes as new potential SREBP-1 targets, in addition to cyclin-dependent kinase inhibitor 1A which had already been described as a gene regulated by SREBP-1a. These data suggested a new role of SREBP-1 in adipogenesis via regulation of preadipocyte proliferation. | - |
| dc.description | Fil: Alvarez, María Soledad. Consejo Superior de Investigaciones Cientificas; España | - |
| dc.description | Fil: Fernández Alvarez, Ana Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina | - |
| dc.description | Fil: Cucarella, Carme. Consejo Superior de Investigaciones Cientificas; España | - |
| dc.description | Fil: Casado Pinna, Marta. Consejo Superior de Investigaciones Cientificas; España | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0006291X14005567 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbrc.2014.03.104 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | SREBP | - |
| dc.subject | Adipocyte | - |
| dc.subject | Bioquímica y Biología Molecular | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Stable SREBP-1a knockdown decreases the cell proliferation rate in human preadipocyte cells without inducing senescence | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.