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dc.provenanceCONICET-
dc.creatorSchor, Ignacio Esteban-
dc.creatorDegner, Jacob F.-
dc.creatorHarnett, Dermot-
dc.creatorCannavò, Enrico-
dc.creatorCasale, Francesco P.-
dc.creatorShim, Heejung-
dc.creatorGarfield, David A.-
dc.creatorBirney, Ewan-
dc.creatorStephens, Matthew-
dc.creatorStegle, Oliver-
dc.creatorFurlong, Eileen E. M.-
dc.date2018-12-04T13:13:12Z-
dc.date2018-12-04T13:13:12Z-
dc.date2017-03-
dc.date2018-10-23T18:08:43Z-
dc.date.accessioned2019-04-29T15:27:43Z-
dc.date.available2019-04-29T15:27:43Z-
dc.date.issued2018-12-04T13:13:12Z-
dc.date.issued2018-12-04T13:13:12Z-
dc.date.issued2017-03-
dc.date.issued2018-10-23T18:08:43Z-
dc.identifierSchor, Ignacio Esteban; Degner, Jacob F.; Harnett, Dermot; Cannavò, Enrico; Casale, Francesco P.; et al.; Promoter shape varies across populations and affects promoter evolution and expression noise; Nature Publishing Group; Nature Genetics; 49; 4; 3-2017; 550-558-
dc.identifier1061-4036-
dc.identifierhttp://hdl.handle.net/11336/65679-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294583-
dc.descriptionAnimal promoters initiate transcription either at precise positions (narrow promoters) or dispersed regions (broad promoters), a distinction referred to as promoter shape. Although highly conserved, the functional properties of promoters with different shapes and the genetic basis of their evolution remain unclear. Here we used natural genetic variation across a panel of 81 Drosophila lines to measure changes in transcriptional start site (TSS) usage, identifying thousands of genetic variants affecting transcript levels (strength) or the distribution of TSSs within a promoter (shape). Our results identify promoter shape as a molecular trait that can evolve independently of promoter strength. Broad promoters typically harbor shape-associated variants, with signatures of adaptive selection. Single-cell measurements demonstrate that variants modulating promoter shape often increase expression noise, whereas heteroallelic interactions with other promoter variants alleviate these effects. These results uncover new functional properties of natural promoters and suggest the minimization of expression noise as an important factor in promoter evolution.-
dc.descriptionFil: Schor, Ignacio Esteban. European Molecular Biology Laboratory Heidelberg; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina-
dc.descriptionFil: Degner, Jacob F.. European Molecular Biology Laboratory; Alemania-
dc.descriptionFil: Harnett, Dermot. European Molecular Biology Laboratory; Alemania-
dc.descriptionFil: Cannavò, Enrico. European Molecular Biology Laboratory; Alemania-
dc.descriptionFil: Casale, Francesco P.. European Bioinformatics Institute; Reino Unido-
dc.descriptionFil: Shim, Heejung. Purdue University; Estados Unidos-
dc.descriptionFil: Garfield, David A.. European Molecular Biology Laboratory; Alemania-
dc.descriptionFil: Birney, Ewan. European Bioinformatics Institute; Reino Unido-
dc.descriptionFil: Stephens, Matthew. University of Chicago; Estados Unidos-
dc.descriptionFil: Stegle, Oliver. European Bioinformatics Institute; Reino Unido-
dc.descriptionFil: Furlong, Eileen E. M.. European Molecular Biology Laboratory; Alemania-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherNature Publishing Group-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/ng.3791-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/ng.3791-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/61185-
dc.subjectQuantitative Trait Loci-
dc.subjectregulatory QTL-
dc.subjecteQTL-
dc.subjectembryonic development-
dc.subjectgenetic variation-
dc.subjectexpression noise-
dc.subjectepistasis-
dc.subjectcore promoter-
dc.subjecttranscriptional start site-
dc.subjecttranscription-
dc.subjectgenetic robustness-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titlePromoter shape varies across populations and affects promoter evolution and expression noise-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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