Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Tavares, Flávio L. | - |
| dc.creator | Peichoto, María Elisa | - |
| dc.creator | Rangel, Danieli de Morais | - |
| dc.creator | Barbaro, Kátia Cristina | - |
| dc.creator | Cirillo, Maria Cristina | - |
| dc.creator | Santoro, Marcelo Larami | - |
| dc.creator | Sano Martins, Ida S. | - |
| dc.date | 2018-04-26T19:57:08Z | - |
| dc.date | 2018-04-26T19:57:08Z | - |
| dc.date | 2011-01 | - |
| dc.date | 2018-04-18T15:17:08Z | - |
| dc.date.accessioned | 2019-04-29T15:27:46Z | - |
| dc.date.available | 2019-04-29T15:27:46Z | - |
| dc.date.issued | 2018-04-26T19:57:08Z | - |
| dc.date.issued | 2018-04-26T19:57:08Z | - |
| dc.date.issued | 2011-01 | - |
| dc.date.issued | 2018-04-18T15:17:08Z | - |
| dc.identifier | Tavares, Flávio L.; Peichoto, María Elisa; Rangel, Danieli de Morais; Barbaro, Kátia Cristina; Cirillo, Maria Cristina; et al.; Loxosceles gaucho spider venom and its sphingomyelinase fraction trigger the main functions of human and rabbit platelets; Sage Publications Ltd; Human and Experimental Toxicoloxy; 30; 10; 1-2011; 1567-1574 | - |
| dc.identifier | 0960-3271 | - |
| dc.identifier | http://hdl.handle.net/11336/43597 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294592 | - |
| dc.description | Loxosceles venoms can promote severe local and systemic damages. We have previously reported that Loxosceles gaucho spider venom causes a severe early thrombocytopenia in rabbits. Herein, we investigated the in vitro effects of this venom and its sphingomyelinase fraction on the main functions of platelets. Whole venom and its fraction induced aggregation of both human and rabbit platelets. Aggregation was dependent of plasma component(s) but independent of venom-induced lysophosphatidic acid generation. There was no increase in the levels of lactate dehydrogenase during platelet aggregation, ruling out the possibility of platelet lysis. The increased expression of ligand-induced binding site 1 (LIBS1) induced by L. gaucho venom and its sphingomyelinase fraction, as well as of P-selectin by the whole venom, evidenced the activation state of both human and rabbit platelets. Adhesion assays showed an irregular response when platelets were exposed to the whole venom, whereas the sphingomyelinase fraction induced a dose-dependent increase in the platelet adhesion to collagen. These findings evidence that L. gaucho venom and its sphingomyelinase fraction trigger adhesion, activation, and aggregation of both human and rabbit platelets. Thus, this work justifies the use of rabbits to investigate Loxosceles venom-induced platelet disturbances, and it also supports research on the role of platelets in the pathogenesis of loxoscelism. | - |
| dc.description | Fil: Tavares, Flávio L.. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil | - |
| dc.description | Fil: Peichoto, María Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina | - |
| dc.description | Fil: Rangel, Danieli de Morais. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil | - |
| dc.description | Fil: Barbaro, Kátia Cristina. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil | - |
| dc.description | Fil: Cirillo, Maria Cristina. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil | - |
| dc.description | Fil: Santoro, Marcelo Larami. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil | - |
| dc.description | Fil: Sano Martins, Ida S.. Governo do Estado de Sao Paulo. Secretaria da Saude. Instituto Butantan; Brasil | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Sage Publications Ltd | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/abs/10.1177/0960327110393761 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/0960327110393761 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | LOXOSCELES GAUCHO | - |
| dc.subject | VENOM | - |
| dc.subject | SPHINGOMYELINASE | - |
| dc.subject | PLATELET ACTIVATION | - |
| dc.subject | PLATELET ADHESION | - |
| dc.subject | PLATELET AGGREGATION | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Loxosceles gaucho spider venom and its sphingomyelinase fraction trigger the main functions of human and rabbit platelets | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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