1. RODNA
  2. CONICET
  3. CONICET
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.creatorBrea, María Soledad-
dc.creatorMorgan, Patricio Eduardo-
dc.creatorPerez, Nestor Gustavo-
dc.date2018-06-20T01:41:02Z-
dc.date2018-06-20T01:41:02Z-
dc.date2017-06-12-
dc.date2018-06-08T14:27:24Z-
dc.date.accessioned2019-04-29T15:28:30Z-
dc.date.available2019-04-29T15:28:30Z-
dc.date.issued2018-06-20T01:41:02Z-
dc.date.issued2018-06-20T01:41:02Z-
dc.date.issued2017-06-12-
dc.date.issued2018-06-08T14:27:24Z-
dc.identifierBrea, María Soledad; Morgan, Patricio Eduardo; Perez, Nestor Gustavo; Intramyocardial gene silencing by interfering RNA; Allied Academies; Journal of RNA and Genomics; 13; 1; 12-6-2017; 550-556-
dc.identifier1747-0854-
dc.identifierhttp://hdl.handle.net/11336/49492-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294779-
dc.descriptionRNAi is a widely used methodology for gene silencing. The action mechanism of siRNA molecules has been well studiedin recent years, and the technique has been optimized in terms of safety and effectiveness. Cardiovascular diseases havea high incidence in the current population, and despite of the extensive research, safe and efficient therapeutics have notyet been found, which is reflected by 17.1 million people who die each year for this cause. In this context, siRNAs arebeing considered a therapeutic tool to regulate the expression of genes involved in the generation of these pathologies.The efficacy of siRNAs entry to cardiomyocytes, the safety of the delivery process and the degree of silencing achievedare main aspects before consider it as a cardiovascular disease therapy. Presently, we will give a brief outline of thecurrent understanding of the RNAi mechanism and the delivery system to the heart. We describe the use of lentivirus fora functional silencing of cardiac proteins in the study of a pathophysiological process, the slow force response to cardiacstretch.-
dc.descriptionFil: Brea, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; Argentina-
dc.descriptionFil: Morgan, Patricio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; Argentina-
dc.descriptionFil: Perez, Nestor Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares ; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherAllied Academies-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.alliedacademies.org/articles/intramyocardial-gene-silencing-by-interfering-rna-7644.ht-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectSIRNA-
dc.subjectHEART-
dc.subjectLENTIVIRUS-
dc.subjectCARDIOMYOCYTE-
dc.subjectFisiología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.subjectSistemas Cardíaco y Cardiovascular-
dc.subjectMedicina Clínica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleIntramyocardial gene silencing by interfering RNA-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
Aparece en las colecciones: CONICET

Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro sencillo del ítem