Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Wasowski, Cristina Lucia N. | - |
| dc.creator | Marder, Nora Mariel | - |
| dc.date | 2017-06-15T00:20:11Z | - |
| dc.date | 2017-06-15T00:20:11Z | - |
| dc.date | 2012-01 | - |
| dc.date | 2017-06-14T14:34:20Z | - |
| dc.date.accessioned | 2019-04-29T15:28:34Z | - |
| dc.date.available | 2019-04-29T15:28:34Z | - |
| dc.date.issued | 2017-06-15T00:20:11Z | - |
| dc.date.issued | 2017-06-15T00:20:11Z | - |
| dc.date.issued | 2012-01 | - |
| dc.date.issued | 2017-06-14T14:34:20Z | - |
| dc.identifier | Wasowski, Cristina Lucia N.; Marder, Nora Mariel; Flavonoids as GABAA receptor ligands: the whole story?; Dove Medical Press; Journal of Experimental Pharmacology; 2012; 4; 1-2012; 9-24 | - |
| dc.identifier | http://hdl.handle.net/11336/18235 | - |
| dc.identifier | 1179-1454 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294796 | - |
| dc.description | Benzodiazepines are the most widely prescribed class of psychoactive drugs in current therapeutic use, despite the important unwanted side effects that they produce, such as sedation, myorelaxation, ataxia, amnesia, and ethanol and barbiturate potentiation and tolerance. They exert their therapeutic effects via binding to the benzodiazepine binding site of gamma-aminobutyric acid (GABA) type A receptors, and allosterically modulating the chloride flux through the ion channel complex. First isolated from plants used as tranquilizers in folkloric medicine, some natural flavonoids have been shown to possess selective affinity for the benzodiazepine binding site with a broad spectrum of central nervous system effects. Since the initial search for alternative benzodiazepine ligands amongst the flavonoids, a list of successful synthetic derivatives has been generated with enhanced activities. This review provides an update on research developments that have established the activity of natural and synthetic flavonoids on GABA type A receptors. Flavonoids are prominent drugs in the treatment of mental disorders, and can also be used as tools to study modulatory sites at GABA type A receptors and to develop GABA type A selective agents further. | - |
| dc.description | Fil: Wasowski, Cristina Lucia N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina | - |
| dc.description | Fil: Marder, Nora Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Dove Medical Press | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/flavonoids-as-gabaa-receptor-ligands-the-whole-story-peer-reviewed-article-JEP | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2147/JEP.S23105 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863311/ | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Flavonoids | - |
| dc.subject | GABA type A receptors | - |
| dc.subject | Benzodiazepine binding site | - |
| dc.subject | Otras Ciencias Químicas | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Flavonoids as GABAA receptor ligands: the whole story? | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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