Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Sena, Angela | - |
| dc.creator | Pedrotti, Luciano Pablo | - |
| dc.creator | Barrios, Bibiana Elisabet | - |
| dc.creator | Cejas, Hugo | - |
| dc.creator | Balderramo, Domingo | - |
| dc.creator | Diller, Ana | - |
| dc.creator | Correa, Silvia Graciela | - |
| dc.date | 2018-05-24T14:26:08Z | - |
| dc.date | 2018-05-24T14:26:08Z | - |
| dc.date | 2015-09 | - |
| dc.date | 2018-05-22T21:47:50Z | - |
| dc.date.accessioned | 2019-04-29T15:28:44Z | - |
| dc.date.available | 2019-04-29T15:28:44Z | - |
| dc.date.issued | 2018-05-24T14:26:08Z | - |
| dc.date.issued | 2018-05-24T14:26:08Z | - |
| dc.date.issued | 2015-09 | - |
| dc.date.issued | 2018-05-22T21:47:50Z | - |
| dc.identifier | Sena, Angela; Pedrotti, Luciano Pablo; Barrios, Bibiana Elisabet; Cejas, Hugo; Balderramo, Domingo; et al.; Lack of TNFRI signaling enhances annexin A1 biological activity in intestinal inflammation; Pergamon-Elsevier Science Ltd; Biochemical Pharmacology; 98; 3; 9-2015; 422-431 | - |
| dc.identifier | 0006-2952 | - |
| dc.identifier | http://hdl.handle.net/11336/46050 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294853 | - |
| dc.description | We evaluated whether the lack of TNF-α signaling increases mucosal levels of annexin A1 (AnxA1); the hypothesis stems from previous findings showing that TNF-α neutralization in Crohn´s disease patients up-regulates systemic AnxA1 expression. Biopsies from healthy volunteers and patients under anti-TNF-α therapy with remittent ulcerative colitis (UC) showed higher AnxA1 expression than those with active disease. We also evaluated dextran sulfate sodium (DSS)-acute colitis in TNF-α receptor 1 KO (TNFR1-/-) strain with impaired TNF-α signaling and C57BL/6 (WT) mice. Although both strains developed colitis, TNFR1-/- mice showed early clinical recovery, lower myeloperoxidase (MPO) activity and milder histopathological alterations. Colonic epithelium from control and DSS-treated TNFR1-/- mice showed intense AnxA1 expression and AnxA1+ CD4+ and CD8+ T cells were more frequent in TNFR1-/- animals, suggesting an extra supply of AnxA1. The pan antagonist of AnxA1 receptors exacerbated the colitis outcome in TNFR1-/- mice, supporting the pivotal role of AnxA1 in the early recovery. Our findings demonstrate that the TNF-α signaling reduction favors the expression and biological activity of AnxA1 in inflamed intestinal mucosa. | - |
| dc.description | Fil: Sena, Angela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina | - |
| dc.description | Fil: Pedrotti, Luciano Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina | - |
| dc.description | Fil: Barrios, Bibiana Elisabet. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina | - |
| dc.description | Fil: Cejas, Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina | - |
| dc.description | Fil: Balderramo, Domingo. Hospital Privado Centro Medico de Córdoba; Argentina | - |
| dc.description | Fil: Diller, Ana. Hospital Privado Centro Medico de Córdoba; Argentina | - |
| dc.description | Fil: Correa, Silvia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Pergamon-Elsevier Science Ltd | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bcp.2015.09.009 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S000629521500619X | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | THERAPY | - |
| dc.subject | DSS-INDUCED COLITIS | - |
| dc.subject | INFLAMMATION | - |
| dc.subject | GUT | - |
| dc.subject | EPITHELIUM | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Lack of TNFRI signaling enhances annexin A1 biological activity in intestinal inflammation | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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