Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Suarez, Irina Paula | - |
| dc.creator | Burdisso, Paula | - |
| dc.creator | Benoit Matthieu P. M. H. | - |
| dc.creator | Boisbouvier, Jerome | - |
| dc.creator | Rasia, Rodolfo Maximiliano | - |
| dc.date | 2018-07-03T20:39:22Z | - |
| dc.date | 2018-07-03T20:39:22Z | - |
| dc.date | 2015-06 | - |
| dc.date | 2018-07-03T13:53:13Z | - |
| dc.date.accessioned | 2019-04-29T15:28:57Z | - |
| dc.date.available | 2019-04-29T15:28:57Z | - |
| dc.date.issued | 2018-07-03T20:39:22Z | - |
| dc.date.issued | 2018-07-03T20:39:22Z | - |
| dc.date.issued | 2015-06 | - |
| dc.date.issued | 2018-07-03T13:53:13Z | - |
| dc.identifier | Suarez, Irina Paula; Burdisso, Paula; Benoit Matthieu P. M. H.; Boisbouvier, Jerome; Rasia, Rodolfo Maximiliano; Induced folding in RNA recognition by Arabidopsis thaliana DCL1; Oxford University Press; Nucleic Acids Research; 43; 13; 6-2015; 6607-6619 | - |
| dc.identifier | 0305-1048 | - |
| dc.identifier | http://hdl.handle.net/11336/51106 | - |
| dc.identifier | 1362-4962 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294921 | - |
| dc.description | DCL1 is the ribonuclease that carries out miRNA biogenesis in plants. The enzyme has two tandem double stranded RNA binding domains (dsRBDs) in its C-terminus. Here we show that the first of these domains binds precursor RNA fragments when isolated and cooperates with the second domain in the recognition of substrate RNA. Remarkably, despite showing RNA binding activity, this domain is intrinsically disordered. We found that it acquires a folded conformation when bound to its substrate, being the first report of a complete dsRBD folding upon binding. The free unfolded form shows tendency to adopt folded conformations, and goes through an unfolded bound state prior to the folding event. The significance of these results is discussed by comparison with the behavior of other dsRBDs. | - |
| dc.description | Fil: Suarez, Irina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina | - |
| dc.description | Fil: Burdisso, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina | - |
| dc.description | Fil: Benoit Matthieu P. M. H.. Institut de Biologie Structurale Jean Pierre Ebel; Francia | - |
| dc.description | Fil: Boisbouvier, Jerome. Institut de Biologie Structurale Jean Pierre Ebel; Francia | - |
| dc.description | Fil: Rasia, Rodolfo Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Oxford University Press | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/nar/gkv627 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/nar/article/43/13/6607/2414337 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | DCL1 | - |
| dc.subject | miRNA | - |
| dc.subject | dsRBDs | - |
| dc.subject | INTRINSICALLY DISORDERED | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Induced folding in RNA recognition by Arabidopsis thaliana DCL1 | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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