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dc.creatorLi, Ying-
dc.creatorMukherjee, Indrani-
dc.creatorThum, Karen E-
dc.creatorTanurdzic, Milos-
dc.creatorKatari, Manpreet S-
dc.creatorObertello, Mariana-
dc.creatorEdwards, Molly B-
dc.creatorMcCombie, W Richard-
dc.creatorMartienssen, Robert A-
dc.creatorCoruzzi, Gloria M-
dc.date2018-05-21T15:36:46Z-
dc.date2018-05-21T15:36:46Z-
dc.date2015-05-
dc.date2018-05-03T21:06:08Z-
dc.date.accessioned2019-04-29T15:29:01Z-
dc.date.available2019-04-29T15:29:01Z-
dc.date.issued2018-05-21T15:36:46Z-
dc.date.issued2018-05-21T15:36:46Z-
dc.date.issued2015-05-
dc.date.issued2018-05-03T21:06:08Z-
dc.identifierLi, Ying; Mukherjee, Indrani; Thum, Karen E; Tanurdzic, Milos; Katari, Manpreet S; et al.; The histone methyltransferase SDG8 mediates the epigenetic modification of light and carbon responsive genes in plants; BioMed Central; Genomebiology.com (london. Print); 16; 1; 5-2015; 1-15-
dc.identifier1465-6906-
dc.identifierhttp://hdl.handle.net/11336/45740-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294949-
dc.descriptionBackground: Histone methylation modifies the epigenetic state of target genes to regulate gene expression in the context of developmental and environmental changes. Previously, we used a positive genetic screen to identify an Arabidopsis mutant, cli186, which was impaired in carbon and light signaling. Here, we report a deletion of the Arabidopsis histone methyltransferase SDG8 in this mutant (renamed sdg8-5), which provides a unique opportunity to study the global function of a specific histone methyltransferase within a multicellular organism. Results: To assess the specific role of SDG8, we examine how the global histone methylation patterns and transcriptome were altered in the sdg8-5 deletion mutant compared to wild type, within the context of transient light and carbon treatments. Our results reveal that the sdg8 deletion is associated with a significant reduction of H3K36me3, preferentially towards the 3′ end of the gene body, accompanied by a reduction in gene expression. We uncover 728 direct targets of SDG8 that have altered methylation in the sdg8-5 mutant and are also bound by SDG8. As a group, this set of SDG8 targets is enriched in specific biological processes including defense, photosynthesis, nutrient metabolism and energy metabolism. Importantly, 64% of these SDG8 targets are responsive to light and/or carbon signals. Conclusions: The histone methyltransferase SDG8 functions to regulate the H3K36 methylation of histones associated with gene bodies in Arabidopsis. The H3K36me3 mark in turn is associated with high-level expression of a specific set of light and/or carbon responsive genes involved in photosynthesis, metabolism and energy production.-
dc.descriptionFil: Li, Ying. University of New York; Estados Unidos-
dc.descriptionFil: Mukherjee, Indrani. University of New York; Estados Unidos-
dc.descriptionFil: Thum, Karen E. University of New York; Estados Unidos-
dc.descriptionFil: Tanurdzic, Milos. Cold Spring Harbor; Estados Unidos. University of Queensland; Australia-
dc.descriptionFil: Katari, Manpreet S. University of New York; Estados Unidos-
dc.descriptionFil: Obertello, Mariana. University of New York; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina-
dc.descriptionFil: Edwards, Molly B. University of New York; Estados Unidos-
dc.descriptionFil: McCombie, W Richard. Cold Spring Harbor; Estados Unidos-
dc.descriptionFil: Martienssen, Robert A. Cold Spring Harbor; Estados Unidos-
dc.descriptionFil: Coruzzi, Gloria M. University of New York; Estados Unidos-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherBioMed Central-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1186/s13059-015-0640-2-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0640-2-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectHISTONE METHYLTRANSFERASE-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleThe histone methyltransferase SDG8 mediates the epigenetic modification of light and carbon responsive genes in plants-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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