Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Rachid, Mirta Maria | - |
| dc.creator | Matar, Chantal | - |
| dc.creator | Duarte, Jairo | - |
| dc.creator | Perdigon, Gabriela del Valle | - |
| dc.date | 2018-02-19T17:53:55Z | - |
| dc.date | 2018-02-19T17:53:55Z | - |
| dc.date | 2006-07 | - |
| dc.date | 2017-08-24T18:59:02Z | - |
| dc.date.accessioned | 2019-04-29T15:29:06Z | - |
| dc.date.available | 2019-04-29T15:29:06Z | - |
| dc.date.issued | 2018-02-19T17:53:55Z | - |
| dc.date.issued | 2018-02-19T17:53:55Z | - |
| dc.date.issued | 2006-07 | - |
| dc.date.issued | 2017-08-24T18:59:02Z | - |
| dc.identifier | Rachid, Mirta Maria; Matar, Chantal; Duarte, Jairo; Perdigon, Gabriela del Valle; Effect of milk fermented with a Lactobacillus helveticus R389(+) proteolytic strain on the immune system and on the growth of 4T1 breast cancer cells in mice; Wiley Blackwell Publishing, Inc; Fems Immunology And Medical Microbiology; 47; 2; 7-2006; 242-253 | - |
| dc.identifier | 0928-8244 | - |
| dc.identifier | http://hdl.handle.net/11336/36724 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/294980 | - |
| dc.description | Previous studies on a murine model have demonstrated that the administration of Lactobacillus helveticus and Lactobacillus casei inhibits the development of fibrosarcoma and colon carcinoma, respectively. The aim of this work was to study the beneficial effects of the consumption of milk fermented by L. helveticus on a murine model for mammary carcinoma. Female BALB/c mice were challenged by a single subcutaneous injection of tumoral cells (American Type Culture Collection 4T1) in the left mammary gland. Prior to tumour injection, mice were fed for two, five or seven consecutive days with fermented milk. The following factors were monitored for 2 months: rate of tumour development, histological studies, apoptosis, phagocytic index, peritoneal macrophages, determination of β-glucuronidase enzyme in peritoneal macrophages, determination of γ-interferon (INFγ) and tumour necrosis factor-α (TNF-α) in blood serum, determination of CD4+, CD8+, interleukin-6 (IL-6), IL-10, TNF-α and INFγ by immunoperoxidase, and measurement of β-glucuronidase activity in intestinal fluid. The administration of L. helveticus delayed the development of the tumour in all cases, a 2- or 7-day feeding period being most effective. This work demonstrates that milk fermented with L. helveticus decreases the growth rate of mammary tumours. The effect was mediated by increased apoptosis and decreased production of pro-inflammatory cytokines, in particular IL-6, implicated in oestrogen synthesis. | - |
| dc.description | Fil: Rachid, Mirta Maria. Universite de Moncton; Canadá. Universidad Nacional de Tucumán; Argentina | - |
| dc.description | Fil: Matar, Chantal. Universite de Moncton; Canadá | - |
| dc.description | Fil: Duarte, Jairo. Universite de Moncton; Canadá | - |
| dc.description | Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Universidad Nacional de Tucumán; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley Blackwell Publishing, Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1574-695X.2006.00088.x | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/femspd/article/47/2/242/548958 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | BREAST CANCER | - |
| dc.subject | FERMENTED MILK | - |
| dc.subject | PROTEOLYTIC STRAIN | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Effect of milk fermented with a Lactobacillus helveticus R389(+) proteolytic strain on the immune system and on the growth of 4T1 breast cancer cells in mice | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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