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dc.creatorSuarez, Maria Fernanda-
dc.creatorCrim, Nicolás-
dc.creatorMonti, Rodolfo-
dc.creatorEsposito, Evangelina-
dc.creatorUrrets Zavalía, Julio Alberto-
dc.creatorSerra, Horacio Marcelo-
dc.date2018-05-30T18:32:38Z-
dc.date2018-05-30T18:32:38Z-
dc.date2015-11-
dc.date2018-05-22T21:49:58Z-
dc.date.accessioned2019-04-29T15:29:15Z-
dc.date.available2019-04-29T15:29:15Z-
dc.date.issued2018-05-30T18:32:38Z-
dc.date.issued2018-05-30T18:32:38Z-
dc.date.issued2015-11-
dc.date.issued2018-05-22T21:49:58Z-
dc.identifierSuarez, Maria Fernanda; Crim, Nicolás; Monti, Rodolfo; Esposito, Evangelina; Urrets Zavalía, Julio Alberto; et al.; Clinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina; Wiley Blackwell Publishing, Inc; Journal of Clinical & Experimental Ophthalmology; 06; 06; 11-2015; 1-8-
dc.identifier2155-9570-
dc.identifierhttp://hdl.handle.net/11336/46689-
dc.identifier1442-6404-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295035-
dc.descriptionObjective: The purpose of our work was to study and compare the cornea and tear film of people and sheep inhabiting in a region of Argentinean Patagonia (PATG), and in a geographically and climatically different region in the Argentinean Pampa (CAPT).Methods: Using cross sectional study, corneal examinations were performed in people and Merino sheep inhabiting PATG and CAPT regions, respectively. All people completed a questionnaire related to work activity, diet, and the use of hats or sunglasses during their life. Eyes from all participants were examined with a portable hand- held slit-lamp biomicroscope (BM) to evaluate corneal appearance, epithelium integrity, and transparency. Later on, in a subgroup of participants we studied eye blinking frequency (EBF), ocular surface staining (FS), breakup time (BUT), Schirmer Tear Test (STT), corneal structure using confocal laser scanning microscopy (CLSM) and light microscopy (LM), and concentrations of serum ascorbate (sAA).Results: BM studies revealed numerous cases of climatic droplet keratopathy (CDK) only in people inhabiting the PATG region. CLSM studies confirmed typical punctate deposits at the Bowman ́s layer in CDK patients living in that region. CLSM images from sheep did not show any abnormalities at the Bowman ́s layer but exhibited small hyper reflective dots at the epithelium only in animals pasturing in the PATG region. FS and EBF mean values were significant higher in sheep grazing in the PATG region (p <0.05). No differences were found in surface eye tests when people from both regions were analyzed. Low sAA levels were found only in CDK people living in PATG region.Conclusions: CDK is a multi-factorial disease not only associated to harsh climate. We provide data that low sAA levels can play a role in its genesis in Patagonia patients?... Sheep pasturing in this region with a high prevalence of CDK have high concentration of sAA and did not present any sub epithelial corneal abnormalities.-
dc.descriptionFil: Suarez, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina-
dc.descriptionFil: Crim, Nicolás. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina-
dc.descriptionFil: Monti, Rodolfo. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina-
dc.descriptionFil: Esposito, Evangelina. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina-
dc.descriptionFil: Urrets Zavalía, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina-
dc.descriptionFil: Serra, Horacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherWiley Blackwell Publishing, Inc-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.4172/2155-9570.1000499-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/clinical-functional-and-structural-studies-of-humans-and-merino-sheepcorneas-from-two-different-regions-of-argentina-2155-9570-1000499.php?aid=66076-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectCLIMATIC DROPLET KERATOPATHY-
dc.subjectCORNEAL DEGENERATION-
dc.subjectARGENTINIAN PATAGONIA-
dc.subjectARGENTINIAN PAMPA-
dc.subjectHUMAN-
dc.subjectSHEEP-
dc.subjectOCULAR SURGACE-
dc.subjectMedicina Critica y de Emergencia-
dc.subjectMedicina Clínica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleClinical, Functional and Structural Studies of Humans and Merino Sheep Corneas from Two Different Regions of Argentina-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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