Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Baldo, M. N. | - |
| dc.creator | Hunzicker, Gabriel Alejandro | - |
| dc.creator | Altamirano, Jorgelina Cecilia | - |
| dc.creator | Murguia, Marcelo Cesar | - |
| dc.creator | Hein, Gustavo Juan | - |
| dc.date | 2016-12-22T14:49:42Z | - |
| dc.date | 2016-12-22T14:49:42Z | - |
| dc.date | 2015-05 | - |
| dc.date | 2016-12-16T14:27:42Z | - |
| dc.date.accessioned | 2019-04-29T15:29:15Z | - |
| dc.date.available | 2019-04-29T15:29:15Z | - |
| dc.date.issued | 2016-12-22T14:49:42Z | - |
| dc.date.issued | 2016-12-22T14:49:42Z | - |
| dc.date.issued | 2015-05 | - |
| dc.date.issued | 2016-12-16T14:27:42Z | - |
| dc.identifier | Baldo, M. N.; Hunzicker, Gabriel Alejandro; Altamirano, Jorgelina Cecilia; Murguia, Marcelo Cesar; Hein, Gustavo Juan; Bioequivalence evaluation of two brands of ketoprofen 50 mg capsules (Flogofin® & Profenid®) in healthy latin american volunteers; OMICS; Journal of Bioequivalence & Bioavailability; 7; 3; 5-2015; 108-111 | - |
| dc.identifier | 0975-0851 | - |
| dc.identifier | http://hdl.handle.net/11336/9909 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295037 | - |
| dc.description | The study was performed to compare the bioavailability of two ketoprofen capsule (50 mg) formulations: Flogofin®, as test formulation, and Profenid®, as reference formulation. The study was conducted open with randomized two period crossover design and 1 week washout period in 24 fasting, healthy latino-american male volunteers and performed at the Biopharmaceutical Research Center Dominguez Lab. After dosing, serial blood samples were collected for a period of 24 h and plasma was separated and analyzed for ketoprofen, using a sensitive, reproducible, and accurate method by liquid chromatography ? tandem mass spectrometry (LC-MS/MS). Pharmacokinetic parameters: AUC0-24, AUC0-∞, Cmax, Tmax, T1/2 and Ke, were analyzed from plasma concentrations of both formulations. The means AUC0-24 for test and reference formulation were 50.21 ([μg h]/mL) - 50.28 ([μgh]/mL), 52.38 ([μg h]/mL) - 50.84 ([μg h]/mL) for AUC0-∞, and 21.58 μg/mL - 21.65 μg/mL for Cmax, respectively. Statistical modules (ANOVA and 90% confidence intervals) were applied to AUC0?24, AUC0-∞, and Cmax to assess the bioequivalence of the two brands which revealed no significant difference between them, and 90% CI fell within the accepted bioequivalence range of 80%-125%. Based on these statistical inferences, both formulations were found to be bioequivalent. | - |
| dc.description | Fil: Baldo, M. N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Ciencias Veterinarias del Litoral; Argentina. Dominguez Lab; Argentina | - |
| dc.description | Fil: Hunzicker, Gabriel Alejandro. Dominguez Lab; Argentina | - |
| dc.description | Fil: Altamirano, Jorgelina Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Científico Tecnológico Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; Argentina | - |
| dc.description | Fil: Murguia, Marcelo Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional de Cuyo; Argentina | - |
| dc.description | Fil: Hein, Gustavo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Ciencias Veterinarias del Litoral; Argentina. Dominguez Lab; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | OMICS | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4172/jbb.1000223 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/bioequivalence-evaluation-of-two-brands-of-ketoprofen-50-mg-capsulesflogofinprofenid-in-healthy-latin-american-volunteers-jbb-1000223.php?aid=49045 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | KETOPROFEN | - |
| dc.subject | BIOAVAILABILITY | - |
| dc.subject | PHARMACOKINETICS | - |
| dc.subject | MASS SPECTROMETRY | - |
| dc.subject | Química Analítica | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Bioequivalence evaluation of two brands of ketoprofen 50 mg capsules (Flogofin® & Profenid®) in healthy latin american volunteers | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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