Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Vianna, Fernanda Sales Luiz | - |
| dc.creator | Oliveira, Marcelo Zagonel de | - |
| dc.creator | Sanseverino, Maria Teresa Vieira | - |
| dc.creator | Morelo, Elaine Faria | - |
| dc.creator | Rabello Neto, Dacio de Lyra | - |
| dc.creator | López Camelo, Jorge Santiago | - |
| dc.creator | Camey, Suzi Alves | - |
| dc.creator | Schuler Faccini, Lavinia | - |
| dc.date | 2018-04-10T19:28:09Z | - |
| dc.date | 2018-04-10T19:28:09Z | - |
| dc.date | 2015-06 | - |
| dc.date | 2018-04-10T14:18:25Z | - |
| dc.date.accessioned | 2019-04-29T15:29:18Z | - |
| dc.date.available | 2019-04-29T15:29:18Z | - |
| dc.date.issued | 2018-04-10T19:28:09Z | - |
| dc.date.issued | 2018-04-10T19:28:09Z | - |
| dc.date.issued | 2015-06 | - |
| dc.date.issued | 2018-04-10T14:18:25Z | - |
| dc.identifier | Vianna, Fernanda Sales Luiz; Oliveira, Marcelo Zagonel de; Sanseverino, Maria Teresa Vieira; Morelo, Elaine Faria; Rabello Neto, Dacio de Lyra; et al.; Pharmacoepidemiology and thalidomide embryopathy surveillance in Brazil; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 53; 6-2015; 63-67 | - |
| dc.identifier | 0890-6238 | - |
| dc.identifier | http://hdl.handle.net/11336/41579 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295058 | - |
| dc.description | Introduction: Thalidomide causes congenital defects in children, such as limb reduction defects. Currently, it is used for a few indications; in Brazil, where leprosy is endemic, thalidomide is used for the treatment of erythema nodosum leprosum, and recent cases of thalidomide embryopathy have been reported. Methods: We analyzed the frequency of births with phenotypes consistent with thalidomide embryopathy (TEP) and correlated this with the distribution of thalidomide and the prevalence of leprosy between 2005 and 2010 in Brazil. Results: A total of 5,889,210 thalidomide tablets were distributed; the prevalence of limb reduction defects was 1.60 (CI95%: 1.54–1.66) and TEP was 0.11 (CI95%: 0.10–0.13) per 10,000 births. Poisson regression showed an increase in cases of TEP and limb reduction defects per 100,000 tablets dispensed. Clusters and geographical isolates were identified in several regions. Conclusions: There is a correlation between thalidomide and TEP showing that thalidomide embryopathy should be monitored in countries where this medication is available. | - |
| dc.description | Fil: Vianna, Fernanda Sales Luiz. Instituto Nacional de Genética Médica Populacional; Brasil. Hospital de Clínicas de Porto Alegre; Brasil. Universidade Federal do Rio Grande do Sul; Brasil | - |
| dc.description | Fil: Oliveira, Marcelo Zagonel de. Instituto Nacional de Genética Médica Populacional; Brasil. Universidade Federal do Rio Grande do Sul; Brasil | - |
| dc.description | Fil: Sanseverino, Maria Teresa Vieira. Instituto Nacional de Genética Médica Populacional; Brasil. Hospital de Clínicas de Porto Alegre; Brasil | - |
| dc.description | Fil: Morelo, Elaine Faria. Programa Nacional da Hanseníase; Brasil | - |
| dc.description | Fil: Rabello Neto, Dacio de Lyra. Ministério da Saúde do Brasilia; Brasil | - |
| dc.description | Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina | - |
| dc.description | Fil: Camey, Suzi Alves. Universidade Federal do Rio Grande do Sul; Brasil | - |
| dc.description | Fil: Schuler Faccini, Lavinia. Hospital de Clínicas de Porto Alegre; Brasil. Instituto Nacional de Genética Médica Populacional; Brasil. Universidade Federal do Rio Grande do Sul; Brasil | - |
| dc.format | application/pdf | - |
| dc.format | application/vnd.openxmlformats-officedocument.wordprocessingml.document | - |
| dc.language | eng | - |
| dc.publisher | Pergamon-Elsevier Science Ltd | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.reprotox.2015.03.007 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0890623815000416 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | PHARMACOEPIDEMOLOGY | - |
| dc.subject | EMBRYOPATHY | - |
| dc.subject | SURVEILLANCE | - |
| dc.subject | Salud Ocupacional | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Pharmacoepidemiology and thalidomide embryopathy surveillance in Brazil | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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