Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Trinchero, Mariela Fernanda | - |
| dc.creator | Buttner, Karina | - |
| dc.creator | Sulkes Cuevas, Jessica N. | - |
| dc.creator | Temprana, Silvio Gabriel | - |
| dc.creator | Fontanet, Paula | - |
| dc.creator | Monzon Salinas, Maria Cristina | - |
| dc.creator | Ledda, Maria Fernanda | - |
| dc.creator | Paratcha, Gustavo | - |
| dc.creator | Schinder, Alejandro Fabián | - |
| dc.date | 2018-06-05T18:58:22Z | - |
| dc.date | 2018-06-05T18:58:22Z | - |
| dc.date | 2017-10 | - |
| dc.date | 2018-06-01T19:26:59Z | - |
| dc.date.accessioned | 2019-04-29T15:29:33Z | - |
| dc.date.available | 2019-04-29T15:29:33Z | - |
| dc.date.issued | 2018-06-05T18:58:22Z | - |
| dc.date.issued | 2018-06-05T18:58:22Z | - |
| dc.date.issued | 2017-10 | - |
| dc.date.issued | 2018-06-01T19:26:59Z | - |
| dc.identifier | Trinchero, Mariela Fernanda; Buttner, Karina; Sulkes Cuevas, Jessica N.; Temprana, Silvio Gabriel; Fontanet, Paula; et al.; High Plasticity of New Granule Cells in the Aging Hippocampus; Elsevier Science; Cell Reports; 21; 5; 10-2017; 1129-1139 | - |
| dc.identifier | 2211-1247 | - |
| dc.identifier | http://hdl.handle.net/11336/47363 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295124 | - |
| dc.description | During aging, the brain undergoes changes that impair cognitive capacity and circuit plasticity, including a marked decrease in production of adultborn hippocampal neurons. It is unclear whether development and integration of those new neurons are also affected by age. Here, we show that adultborn granule cells (GCs) in aging mice are scarce and exhibit slow development, but they display a remarkable potential for structural plasticity. Retrovirally labeled 3-week-old GCs in middle-aged mice were small, underdeveloped, and disconnected. Neuronal development and integration were accelerated by voluntary exercise or environmental enrichment. Similar effects were observed via knockdown of Lrig1, an endogenous negative modulator of neurotrophin receptors. Consistently, blocking neurotrophin signaling by Lrig1 overexpression abolished the positive effects of exercise. These results demonstrate an unparalleled degree of plasticity in the aging brain mediated by neurotrophins, whereby new GCs remain immature until becoming rapidly recruited to the network by activity. | - |
| dc.description | Fil: Trinchero, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Instituto Leloir; Argentina | - |
| dc.description | Fil: Buttner, Karina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Instituto Leloir; Argentina | - |
| dc.description | Fil: Sulkes Cuevas, Jessica N.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Instituto Leloir; Argentina | - |
| dc.description | Fil: Temprana, Silvio Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Instituto Leloir; Argentina | - |
| dc.description | Fil: Fontanet, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina | - |
| dc.description | Fil: Monzon Salinas, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Instituto Leloir; Argentina | - |
| dc.description | Fil: Ledda, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina | - |
| dc.description | Fil: Paratcha, Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina | - |
| dc.description | Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Instituto Leloir; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Science | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.celrep.2017.09.064 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell-reports/abstract/S2211-1247(17)31354-2 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | ADULT NEUROGENESIS | - |
| dc.subject | DENTATE GYRUS | - |
| dc.subject | EXERCISE | - |
| dc.subject | FUNCTIONAL INTEGRATION | - |
| dc.subject | NEUROTROPHINS | - |
| dc.subject | SYNAPTOGENESIS | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | High Plasticity of New Granule Cells in the Aging Hippocampus | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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