Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Rodríguez, María Eugenia | - |
| dc.creator | Brunetti, Jesús Emanuel | - |
| dc.creator | Wachsman, Mónica Beatriz | - |
| dc.creator | Scolaro, Luis Alberto | - |
| dc.creator | Castilla, Viviana | - |
| dc.date | 2018-01-03T20:09:22Z | - |
| dc.date | 2018-01-03T20:09:22Z | - |
| dc.date | 2014-04 | - |
| dc.date | 2017-12-29T14:20:57Z | - |
| dc.date.accessioned | 2019-04-29T15:29:35Z | - |
| dc.date.available | 2019-04-29T15:29:35Z | - |
| dc.date.issued | 2018-01-03T20:09:22Z | - |
| dc.date.issued | 2018-01-03T20:09:22Z | - |
| dc.date.issued | 2014-04 | - |
| dc.date.issued | 2017-12-29T14:20:57Z | - |
| dc.identifier | Castilla, Viviana; Scolaro, Luis Alberto; Wachsman, Mónica Beatriz; Brunetti, Jesús Emanuel; Rodríguez, María Eugenia; Raf/MEK/ERK pathway activation is required for Junín virus replication; Society for General Microbiology; Journal of General Virology; 95; 4-2014; 799-805 | - |
| dc.identifier | 0022-1317 | - |
| dc.identifier | http://hdl.handle.net/11336/32209 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295135 | - |
| dc.description | In the present work we investigated the importance of the Raf/MEK/ERK signalling pathway in the multiplication of the arenavirus Junı´n (JUNV) in monkey and human cell cultures. We established that JUNV induces a biphasic activation of ERK and we proved that a specific inhibitor of the ERK pathway, U0126, impairs viral replication. Furthermore, U0126 exerted inhibitory action against the arenaviruses Tacaribe and Pichinde. Moreover, treatment with known ERK activators such as phorbol 12-myristate 13-acetate and serum increased viral yields whereas ERK silencing by small interfering RNAs caused the inhibition of viral multiplication. Therefore, activation of the Raf/MEK/ ERK signalling pathway is required to ensure efficient JUNV replication and may constitute a host target for the development of novel effective therapeutic strategies to deal with arenavirus infections. | - |
| dc.description | Fil: Rodríguez, María Eugenia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina | - |
| dc.description | Fil: Brunetti, Jesús Emanuel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Wachsman, Mónica Beatriz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina | - |
| dc.description | Fil: Scolaro, Luis Alberto. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Castilla, Viviana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Society for General Microbiology | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1099/vir.0.061242-0 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.061242-0 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | JUNIN VIRUS | - |
| dc.subject | RAF/MEK/ERK | - |
| dc.subject | CELLULAR PATHWAY | - |
| dc.subject | REPLICATION | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Raf/MEK/ERK pathway activation is required for Junín virus replication | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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