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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Sabin, Guilherme P. | - |
| dc.creator | Lozano, Valeria Antonella | - |
| dc.creator | Rocha, Werickson F. C. | - |
| dc.creator | Romão, Wanderson | - |
| dc.creator | Ortiz, Rafael S. | - |
| dc.creator | Poppi, Ronei J. | - |
| dc.date | 2016-06-03T15:33:20Z | - |
| dc.date | 2016-06-03T15:33:20Z | - |
| dc.date | 2013-11 | - |
| dc.date | 2016-06-01T13:32:33Z | - |
| dc.date.accessioned | 2019-04-29T15:30:08Z | - |
| dc.date.available | 2019-04-29T15:30:08Z | - |
| dc.date.issued | 2013-11 | - |
| dc.identifier | Sabin, Guilherme P.; Lozano, Valeria Antonella; Rocha, Werickson F. C.; Romão, Wanderson; Ortiz, Rafael S.; et al.; Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools; Elsevier; Journal of Pharmaceutical and Biomedical Analysis; 85; 11-2013; 207-212 | - |
| dc.identifier | 0731-7085 | - |
| dc.identifier | http://hdl.handle.net/11336/6028 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295288 | - |
| dc.description | The chemical imaging technique by near infrared spectroscopy was applied for characterization of formulations in tablets of sildenafil citrate of six different sources. Five formulations were provided by Brazilian Federal Police and correspond to several trademarks of prohibited marketing and one was an authentic sample of Viagra. In a first step of the study, multivariate curve resolution was properly chosen for the estimation of the distribution map of concentration of the active ingredient in tablets of different sources, where the chemical composition of all excipients constituents was not truly known. In such cases, it is very difficult to establish an appropriate calibration technique, so that only the information of sildenafil is considered independently of the excipients. This determination was possible only by reaching the second-order advantage, where the analyte quantification can be performed in the presence of unknown interferences. In a second step, the normalized histograms of images from active ingredient were grouped according to their similarities by hierarchical cluster analysis. Finally it was possible to recognize the patterns of distribution maps of concentration of sildenafil citrate, distinguishing the true formulation of Viagra. This concept can be used to improve the knowledge of industrial products and processes, as well as, for characterization of counterfeit drugs. | - |
| dc.description | Fil: Sabin, Guilherme P.. Universidade Estadual de Campinas; Brasil | - |
| dc.description | Fil: Lozano, Valeria Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina | - |
| dc.description | Fil: Rocha, Werickson F. C.. National Institute of Metrology, Quality and Technology. Directorate of Industrial and Scientific Metrology. Chemical Metrology Division; Brasil | - |
| dc.description | Fil: Romão, Wanderson. Instituto Federal de Educação, Ciência e Tecnologia do Spirito Santo; Brasil | - |
| dc.description | Fil: Ortiz, Rafael S.. Policia Federal Brasileira; Brasil | - |
| dc.description | Fil: Poppi, Ronei J.. Universidade Estadual de Campinas; Brasil | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0731708513003427 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jpba.2013.07.036 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2013.07.036 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/6028 | - |
| dc.subject | SILDENAFIL CITRATE | - |
| dc.subject | CHEMICAL IMAGING | - |
| dc.subject | NEAR INFRARED SPECTROSCOPY | - |
| dc.subject | MULTIVARIATE CURVE RESOLUTION | - |
| dc.subject | CLASSIFICATION | - |
| dc.subject | PATTERN RECOGNITION | - |
| dc.subject | Química Analítica | - |
| dc.subject | Ciencias Químicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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