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dc.provenanceCONICET-
dc.creatorGarcía, Adolfo Martín-
dc.creatorSedeño, Lucas-
dc.creatorTrujillo, Natalia-
dc.creatorBocanegra, Yamile-
dc.creatorGomez, Diana-
dc.creatorPineda, David-
dc.creatorVillegas, Andrés-
dc.creatorMuñoz, Edinson-
dc.creatorArias, William-
dc.creatorIbáñez Barassi, Agustín Mariano-
dc.date2018-12-14T17:25:52Z-
dc.date2018-12-14T17:25:52Z-
dc.date2017-02-
dc.date2018-11-02T17:30:47Z-
dc.date.accessioned2019-04-29T15:30:16Z-
dc.date.available2019-04-29T15:30:16Z-
dc.date.issued2017-02-
dc.identifierGarcía, Adolfo Martín; Sedeño, Lucas; Trujillo, Natalia; Bocanegra, Yamile; Gomez, Diana; et al.; Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers; Cambridge University Press; Journal of the International Neuropsychological Society : Jins; 23; 2; 2-2017; 150-158-
dc.identifier1355-6177-
dc.identifierhttp://hdl.handle.net/11336/66502-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295302-
dc.descriptionObjectives: The worldwide spread of Parkinson's disease (PD) calls for sensitive and specific measures enabling its early (or, ideally, preclinical) detection. Here, we use language measures revealing deficits in PD to explore whether similar disturbances are present in asymptomatic individuals at risk for the disease. Methods: We administered executive, semantic, verb-production, and syntactic tasks to sporadic PD patients, genetic PD patients with PARK2 (parkin) or LRRK2 (dardarin) mutation, asymptomatic first-degree relatives of the latter with similar mutations, and socio-demographically matched controls. Moreover, to detect sui generis language disturbances, we ran analysis of covariance tests using executive functions as covariate. Results: The two clinical groups showed impairments in all measures, most of which survived covariation with executive functions. However, the key finding concerned asymptomatic mutation carriers. While these subjects showed intact executive, semantic, and action-verb production skills, they evinced deficits in a syntactic test with minimal working memory load. Conclusions: We propose that this sui generis disturbance may constitute a prodromal sign anticipating eventual development of PD. Moreover, our results suggest that mutations on specific genes (PARK2 and LRRK2) compromising basal ganglia functioning may be subtly related to language-processing mechanisms.-
dc.descriptionFil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina-
dc.descriptionFil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina-
dc.descriptionFil: Trujillo, Natalia. Universidad de Antioquia; Colombia-
dc.descriptionFil: Bocanegra, Yamile. Universidad de Antioquia; Colombia-
dc.descriptionFil: Gomez, Diana. Universidad de Antioquia; Colombia-
dc.descriptionFil: Pineda, David. Universidad de Antioquia; Colombia-
dc.descriptionFil: Villegas, Andrés. Universidad de Antioquia; Colombia-
dc.descriptionFil: Muñoz, Edinson. Universidad de Santiago de Chile; Chile-
dc.descriptionFil: Arias, William. Universidad de Antioquia; Colombia-
dc.descriptionFil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Macquarie University; Australia-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherCambridge University Press-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/journal-of-the-international-neuropsychological-society/article/language-deficits-as-a-preclinical-window-into-parkinsons-disease-evidence-from-asymptomatic-parkin-and-dardarin-mutation-carriers/6C22AB82F0021384939B330267742C7F-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1017/S1355617716000710-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/66502-
dc.subjectGENETIC PARKINSON'S DISEASE-
dc.subjectLANGUAGE-
dc.subjectLRRK2-
dc.subjectPARK2-
dc.subjectPRECLINICAL MUTATION CARRIERS-
dc.subjectSPORADIC PARKINSON'S DISEASE-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleLanguage Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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