Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Cano Barquilla, Pilar | - |
| dc.creator | Pagano, Eleonora Samanta | - |
| dc.creator | Jiménez Ortega, Vanesa | - |
| dc.creator | Fernández Mateos, Pilar | - |
| dc.creator | Esquifino, Ana I. | - |
| dc.creator | Cardinali, Daniel Pedro | - |
| dc.date | 2017-12-12T21:25:17Z | - |
| dc.date | 2017-12-12T21:25:17Z | - |
| dc.date | 2014-09 | - |
| dc.date | 2017-12-12T18:28:36Z | - |
| dc.date.accessioned | 2019-04-29T15:30:30Z | - |
| dc.date.available | 2019-04-29T15:30:30Z | - |
| dc.date.issued | 2014-09 | - |
| dc.identifier | Cano Barquilla, Pilar; Pagano, Eleonora Samanta; Jiménez Ortega, Vanesa; Fernández Mateos, Pilar; Esquifino, Ana I.; et al.; Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats; Wiley; Journal of Pineal Research; 57; 3; 9-2014; 280-290 | - |
| dc.identifier | 0742-3098 | - |
| dc.identifier | http://hdl.handle.net/11336/30363 | - |
| dc.identifier | 1600-079X | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295380 | - |
| dc.description | The objective of this study was to evaluate the efficacy of melatonin to affect mild inflammation in the metabolic syndrome (MS) induced by a high-fat diet in rats. Adult Wistar male rats were divided into four groups (n = 16/group): (i) control diet (3% fat); (ii) high-fat (35%) diet; (iii) high-fat diet + melatonin; and (iv) melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions for 10 wk: (a) tap water; (b) 25 μg/mL of melatonin. Plasma interleukin (IL)-1β, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and C-reactive protein (CRP) were measured at two time intervals, that is, the middle of daylight period and the middle of the scotophase. In addition, a number of somatic and metabolic components employed clinically to monitor the MS were measured. Melatonin decreased the augmented circulating levels of IL-1β, IL-6, TNF-α, IFN-γ, and CRP seen in obese rats and restored the depressed levels of IL-4 and IL-10. Rats fed with the high-fat diet showed significantly higher body weights and augmented systolic blood pressure from the third and fourth week onwards, respectively, melatonin effectively preventing these changes. In high-fat-fed rats, circulating low-density lipoprotein-cholesterol, total cholesterol, and triglyceride concentration augmented significantly, melatonin being effective to counteract these changes. Melatonin-treated rats showed a decreased insulin resistance, the highest values of plasma high-density lipoprotein-cholesterol, and the lowest values of plasma uric acid. The results indicate that melatonin is able to normalize the altered biochemical pro-inflammatory profile seen in rats fed with a high-fat diet. | - |
| dc.description | Fil: Cano Barquilla, Pilar. Universidad Complutense de Madrid; España | - |
| dc.description | Fil: Pagano, Eleonora Samanta. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina | - |
| dc.description | Fil: Jiménez Ortega, Vanesa. Universidad Complutense de Madrid; España | - |
| dc.description | Fil: Fernández Mateos, Pilar. Universidad Complutense de Madrid; España | - |
| dc.description | Fil: Esquifino, Ana I.. Universidad Complutense de Madrid; España | - |
| dc.description | Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jpi.12168 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/jpi.12168/abstract | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/30363 | - |
| dc.subject | CYTOKINES | - |
| dc.subject | DYSLIPIDEMIA | - |
| dc.subject | GLUCOSE TOLERANCE | - |
| dc.subject | HIGH-FAT DIET | - |
| dc.subject | HYPERTENSION | - |
| dc.subject | INFLAMMATION | - |
| dc.subject | URIC ACID | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet-induced metabolic syndrome in rats | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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