Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Quarleri, Jorge Fabian | - |
| dc.date | 2017-12-11T22:52:38Z | - |
| dc.date | 2017-12-11T22:52:38Z | - |
| dc.date | 2014-01 | - |
| dc.date | 2017-12-11T16:43:11Z | - |
| dc.date.accessioned | 2019-04-29T15:30:55Z | - |
| dc.date.available | 2019-04-29T15:30:55Z | - |
| dc.date.issued | 2014-01 | - |
| dc.identifier | Quarleri, Jorge Fabian; Core promoter: A critical region where the hepatitis B virus makes decisions; Baishideng Publishing Group; World Journal of Gastroenterology; 20; 2; 1-2014; 425-435 | - |
| dc.identifier | 1007-9327 | - |
| dc.identifier | http://hdl.handle.net/11336/30230 | - |
| dc.identifier | 2219-2840 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295525 | - |
| dc.description | The core promoter (CP) of the viral genome plays an important role for hepatitis B virus (HBV) replication as it directs initiation of transcription for the synthesis of both the precore and pregenomic (pg) RNAs. The CP consists of the upper regulatory region and the basal core promoter (BCP). The CP overlaps with the 3’-end of the X open reading frames and the 5’-end of the precore region, and contains cis-acting elements that can independently direct transcription of the precore mRNA and pgRNA. Its transcription regulation is under strict control of viral and cellular factors. Even though this regulatory region exhibits high sequence conservation, when variations appear, they may contribute to the persistence of HBV within the host, leading to chronic infection and cirrhosis, and eventually, hepatocellular carcinoma. Among CP sequence variations, those occurring at BCP may dysregulate viral gene expression with emphasis in the hepatitis B e antigen, and contribute to disease progression. In this review these molecular aspects and pathologic topics of core promoter are deeply evaluated. | - |
| dc.description | Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Baishideng Publishing Group | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923017/ | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1007-9327/full/v20/i2/425.htm | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3748/wjg.v20.i2.425 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Hepatitis B virus | - |
| dc.subject | Core promoter | - |
| dc.subject | Variants | - |
| dc.subject | Basal core promoter | - |
| dc.subject | Transcription regulation | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Core promoter: A critical region where the hepatitis B virus makes decisions | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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