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dc.creatorBarfield, C. A.-
dc.creatorBarney, R. S.-
dc.creatorCrudder, C. H.-
dc.creatorWilmoth, J. L.-
dc.creatorStevens; D. S.-
dc.creatorMora Garcia, Santiago-
dc.creatorYanovsky, Marcelo Javier-
dc.creatorWeigl, B. H.-
dc.creatorYanovsky, J.-
dc.date2017-03-09T21:33:40Z-
dc.date2017-03-09T21:33:40Z-
dc.date2011-03-
dc.date2017-02-07T13:52:14Z-
dc.date.accessioned2019-04-29T15:31:01Z-
dc.date.available2019-04-29T15:31:01Z-
dc.date.issued2011-03-
dc.identifierBarfield, C. A.; Barney, R. S.; Crudder, C. H.; Wilmoth, J. L.; Stevens; D. S.; et al.; A highly sensitive rapid diagnostic test for Chagas disease that utilizes a recombinant Trypanosoma cruzi antigen; Institute Of Electrical And Electronics Engineers; Ieee Transactions On Bio-medical Engineering; 58; 3; 3-2011; 814-817-
dc.identifier0018-9294-
dc.identifierhttp://hdl.handle.net/11336/13720-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295563-
dc.descriptionImproved diagnostic tests for Chagas disease are urgently needed. A new lateral flow rapid test for Chagas disease is under development at PATH, in collaboration with Laboratorio Lemos of Argentina, which utilizes a recombinant antigen for detection of antibodies to Trypanosoma cruzi. To evaluate the performance of this test, 375 earlier characterized serum specimens from a region where Chagas is endemic were tested using a reference test (the Ortho T. cruzi ELISA, Johnson & Johnson), a commercially available rapid test (Chagas STAT-PAK, Chembio), and the PATH-Lemos rapid test. Compared to the composite reference tests, the PATH-Lemos rapid test demonstrated an optimal sensitivity of 99.5% and specificity of 96.8%, while the Chagas STAT-PAK demonstrated a sensitivity of 95.3% and specificity of 99.5%. These results indicate that the PATH-Lemos rapid test shows promise as an improved and reliable tool for screening and diagnosis of Chagas disease.-
dc.descriptionFil: Barfield, C. A.. PATH; Estados Unidos-
dc.descriptionFil: Barney, R. S.. PATH; Estados Unidos-
dc.descriptionFil: Crudder, C. H.. PATH; Estados Unidos-
dc.descriptionFil: Wilmoth, J. L.. PATH; Estados Unidos-
dc.descriptionFil: Stevens; D. S.. PATH; Estados Unidos-
dc.descriptionFil: Mora Garcia, Santiago. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Yanovsky, Marcelo Javier. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Weigl, B. H.. PATH; Estados Unidos-
dc.descriptionFil: Yanovsky, J.. Laboratorio Lemos; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherInstitute Of Electrical And Electronics Engineers-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://ieeexplore.ieee.org/document/5601750/-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1109/TBME.2010.2087334-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectChagas disease-
dc.subjectImmunoassay-
dc.subjectMedical diagnosis-
dc.subjectPoint of care-
dc.subjectEnfermedades Infecciosas-
dc.subjectCiencias de la Salud-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleA highly sensitive rapid diagnostic test for Chagas disease that utilizes a recombinant Trypanosoma cruzi antigen-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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