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dc.creatorHessell, Ann J.-
dc.creatorJaworski, Juan Pablo-
dc.creatorEpson, Erin-
dc.creatorMatsuda, Kenta-
dc.creatorPandey, Shilpi-
dc.creatorKahl, Christoph-
dc.creatorReed, Jason-
dc.creatorSutton, William F.-
dc.creatorHammond, Katherine B.-
dc.creatorCheever, Tracy A.-
dc.creatorBarnette, Philip T.-
dc.creatorLegasse, Alfred W.-
dc.creatorPlaner, Shannon-
dc.creatorStanton, Jeffrey J.-
dc.creatorPegu, Amarendra-
dc.creatorChen, Xuejun-
dc.creatorWang, Keyun-
dc.creatorSiess, Don-
dc.creatorBurke, David-
dc.creatorPark, Byung S.-
dc.creatorAxthelm, Michael K-
dc.creatorLewis, Anne-
dc.creatorHirsch, Vanessa M.-
dc.creatorGraham, Barney S.-
dc.creatorMascola, John R.-
dc.creatorSacha, Jonah B.-
dc.creatorHaigwood, Nancy L.-
dc.date2018-05-07T21:29:01Z-
dc.date2018-05-07T21:29:01Z-
dc.date2016-03-
dc.date2018-05-03T13:57:46Z-
dc.date.accessioned2019-04-29T15:31:25Z-
dc.date.available2019-04-29T15:31:25Z-
dc.date.issued2016-03-
dc.identifierHessell, Ann J.; Jaworski, Juan Pablo; Epson, Erin; Matsuda, Kenta; Pandey, Shilpi; et al.; Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques; Nature Publishing Group; Nature Medicine; 22; 4; 3-2016; 362-368-
dc.identifier1078-8956-
dc.identifierhttp://hdl.handle.net/11336/44381-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295718-
dc.descriptionPrevention of mother-to-child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested HIV-1–specific human neutralizing monoclonal antibodies (NmAbs) as a post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaques were inoculated orally with the simian-human immunodeficiency virus SHIVSF162P3. On days 1, 4, 7 and 10 after virus exposure, we injected animals subcutaneously with NmAbs and quantified systemic distribution of NmAbs in multiple tissues within 24 h after antibody administration. Replicating virus was found in multiple tissues by day 1 in animals that were not treated. All NmAb-treated macaques were free of virus in blood and tissues at 6 months after exposure. We detected no anti-SHIV T cell responses in blood or tissues at necropsy, and no virus emerged after CD8+ T cell depletion. These results suggest that early passive immunotherapy can eliminate early viral foci and thereby prevent the establishment of viral reservoirs.-
dc.descriptionFil: Hessell, Ann J.. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Jaworski, Juan Pablo. Oregon Health and Science University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Epson, Erin. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Matsuda, Kenta. National Institutes of Health; Estados Unidos-
dc.descriptionFil: Pandey, Shilpi. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Kahl, Christoph. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Reed, Jason. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Sutton, William F.. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Hammond, Katherine B.. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Cheever, Tracy A.. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Barnette, Philip T.. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Legasse, Alfred W.. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Planer, Shannon. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Stanton, Jeffrey J.. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Pegu, Amarendra. National Institutes of Health; Estados Unidos-
dc.descriptionFil: Chen, Xuejun. National Institutes of Health; Estados Unidos-
dc.descriptionFil: Wang, Keyun. National Institutes of Health; Estados Unidos-
dc.descriptionFil: Siess, Don. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Burke, David. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Park, Byung S.. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Axthelm, Michael K. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Lewis, Anne. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Hirsch, Vanessa M.. National Institutes of Health; Estados Unidos-
dc.descriptionFil: Graham, Barney S.. National Institutes of Health; Estados Unidos-
dc.descriptionFil: Mascola, John R.. National Institutes of Health; Estados Unidos-
dc.descriptionFil: Sacha, Jonah B.. Oregon Health and Science University; Estados Unidos-
dc.descriptionFil: Haigwood, Nancy L.. Oregon Health and Science University; Estados Unidos-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherNature Publishing Group-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/nm.4063-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nm.4063-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectHIV-
dc.subjectAnticuerpos Neutralizantes-
dc.subjectPatogenia-
dc.subjectTransmision Perinatal-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleEarly short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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