Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Glisoni, Romina Julieta | - |
| dc.creator | Sosnik, Alejandro Dario | - |
| dc.date | 2017-12-14T18:02:47Z | - |
| dc.date | 2017-12-14T18:02:47Z | - |
| dc.date | 2014-08 | - |
| dc.date | 2017-12-14T13:48:06Z | - |
| dc.date.accessioned | 2019-04-29T15:32:02Z | - |
| dc.date.available | 2019-04-29T15:32:02Z | - |
| dc.date.issued | 2017-12-14T18:02:47Z | - |
| dc.date.issued | 2017-12-14T18:02:47Z | - |
| dc.date.issued | 2014-08 | - |
| dc.date.issued | 2017-12-14T13:48:06Z | - |
| dc.identifier | Glisoni, Romina Julieta; Sosnik, Alejandro Dario; Novel Poly(Ethylene Oxide)-b-Poly(Propylene Oxide) Copolymer-Glucose Conjugate by the Microwave-Assisted Ring Opening of a Sugar Lactone; Wiley VCH Verlag; Macromolecular Bioscience; 14; 11; 8-2014; 1639-1651 | - |
| dc.identifier | 1616-5187 | - |
| dc.identifier | http://hdl.handle.net/11336/30659 | - |
| dc.identifier | 1616-5195 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/295916 | - |
| dc.description | In this work, we investigated for the first time the conjugation of gluconolactone to a poly(ethylene oxide)-poly(propylene oxide) block copolymer by a microwave-assisted ring opening reaction. The glucosylated copolymer was obtained with high yield(90%). A conjugation extent of approximately 100% was achieved within 15 min. The modification reduced the critical micellar concentration and increased the size of the micelles. The agglutination of the modified polymeric micelles by a soluble lectin that binds glucose confirmed the recognizability of the modified nanocarrier. Finally, the solubilization of darunavir, an anti-HIV protease inhibitor, showed a sharp increase of the aqueous solubility from 91 microgram/mL to 14.2 and 18.9 mg/mL for 10% w/v pristine and glucosylated polymeric micelles, respectively. | - |
| dc.description | Fil: Glisoni, Romina Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina | - |
| dc.description | Fil: Sosnik, Alejandro Dario. Technion - Israel Institute of Technology; Israel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley VCH Verlag | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/mabi.201400235 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/mabi.201400235/abstract | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | GLUCONOLACTONE | - |
| dc.subject | POLYMERIC MICELLES | - |
| dc.subject | DARUNAVIR | - |
| dc.subject | MW ASSISTED SYNTHESIS | - |
| dc.subject | Nano-materiales | - |
| dc.subject | Nanotecnología | - |
| dc.subject | INGENIERÍAS Y TECNOLOGÍAS | - |
| dc.title | Novel Poly(Ethylene Oxide)-b-Poly(Propylene Oxide) Copolymer-Glucose Conjugate by the Microwave-Assisted Ring Opening of a Sugar Lactone | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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