Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Sánchez Borzone, Mariela E. | - |
| dc.creator | Attademo, Andres Maximiliano | - |
| dc.creator | Baiardi, Gustavo Carlos | - |
| dc.creator | Celis, María Ester | - |
| dc.date | 2018-09-11T15:16:25Z | - |
| dc.date | 2018-09-11T15:16:25Z | - |
| dc.date | 2007-07 | - |
| dc.date | 2018-08-13T17:08:17Z | - |
| dc.date.accessioned | 2019-04-29T15:32:15Z | - |
| dc.date.available | 2019-04-29T15:32:15Z | - |
| dc.date.issued | 2018-09-11T15:16:25Z | - |
| dc.date.issued | 2018-09-11T15:16:25Z | - |
| dc.date.issued | 2007-07 | - |
| dc.date.issued | 2018-08-13T17:08:17Z | - |
| dc.identifier | Sánchez Borzone, Mariela E.; Attademo, Andres Maximiliano; Baiardi, Gustavo Carlos; Celis, María Ester; Effect of β-adrenoceptors on the behaviour induced by the neuropeptide glutamic acid isoleucine amide; Elsevier Science; European Journal of Pharmacology; 568; 1-3; 7-2007; 186-191 | - |
| dc.identifier | 0014-2999 | - |
| dc.identifier | http://hdl.handle.net/11336/59030 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296010 | - |
| dc.description | Excessive grooming behaviour is induced by intracerebroventricular injections of the neuropeptide glutamic acid isoleucine amide (neuropeptide-EI), via the activation of A-10 dopaminergic neurons and the noradrenergic system. Our object was to study the latter system involved in these behaviours, using male Wistar rats weighing 250-300 g with i.c.v. implants. The results show that all the adrenoceptor antagonists "per se" do not affect excessive grooming behaviour or motor activity. Intracerebroventricular administration of propranolol, a general β-adrenoceptor antagonist, before neuropeptide-EI, inhibited the induced excessive grooming behaviour in a dose dependent manner. Metoprolol, a β1-adrenoceptor antagonist, also blocked this behaviour. However, intracerebroventricular injections of phentolamine, an α-adrenoceptor antagonist, and ((±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol), a β2-adrenoceptor antagonist, had no effect on the behaviour induced by neuropeptide-EI induced behaviour for any of the doses tested. On the other hand, isoproterenol, a general β-adrenoceptor agonist and dobutamine, a β1-adrenoceptor agonist, both elicited similar behaviours as those induced by neuropeptide-EI. These results support the hypothesis that a relationship exists between neuropeptide-EI and β-adrenoceptors, more specifically the β1-adrenoceptor, as found with other similar endogenous peptides such as neurotensin, cholecystin, substance P and α-melanocyte stimulating hormone. Hence, neuropeptide-EI could probably be exerting a neuromodulating effect on the central nervous system. © 2007 Elsevier B.V. All rights reserved. | - |
| dc.description | Fil: Sánchez Borzone, Mariela E.. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bacteriología y Virología Médica. Laboratorio de Ciencias Fisiológicas; Argentina | - |
| dc.description | Fil: Attademo, Andres Maximiliano. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bacteriología y Virología Médica. Laboratorio de Ciencias Fisiológicas; Argentina. Universidad Nacional del Litoral. Facultad de Humanidades y Ciencias. Laboratorio de Ecotoxicologia; Argentina | - |
| dc.description | Fil: Baiardi, Gustavo Carlos. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bacteriología y Virología Médica. Laboratorio de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina | - |
| dc.description | Fil: Celis, María Ester. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Bacteriología y Virología Médica. Laboratorio de Ciencias Fisiológicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Science | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014299907004797 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ejphar.2007.04.024 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | EXCESSIVE GROOMING BEHAVIOUR | - |
| dc.subject | I.C.V. INJECTION | - |
| dc.subject | NEUROPEPTIDE EI | - |
| dc.subject | NORADRENERGIC SYSTEM | - |
| dc.subject | Medicina Tropical | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Effect of β-adrenoceptors on the behaviour induced by the neuropeptide glutamic acid isoleucine amide | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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