Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | de Erausquin, Gabriel Alejandro | - |
| dc.creator | Hyrc, Krzyztof | - |
| dc.creator | Dorsey, David A. | - |
| dc.creator | Mamah, Daniel | - |
| dc.creator | Dokucu, Mehmet | - |
| dc.creator | Masco, Daniel Hugo | - |
| dc.creator | Walton, Timothy | - |
| dc.creator | Dikranian, Krikor | - |
| dc.creator | Soriano, Mario | - |
| dc.creator | Garcia Verdugo, José Manuel | - |
| dc.creator | Goldberg, Mark P. | - |
| dc.creator | Dugan, Laura L. | - |
| dc.date | 2019-01-02T15:15:26Z | - |
| dc.date | 2019-01-02T15:15:26Z | - |
| dc.date | 2003-04-01 | - |
| dc.date | 2018-11-12T13:45:21Z | - |
| dc.date.accessioned | 2019-04-29T15:32:32Z | - |
| dc.date.available | 2019-04-29T15:32:32Z | - |
| dc.date.issued | 2019-01-02T15:15:26Z | - |
| dc.date.issued | 2019-01-02T15:15:26Z | - |
| dc.date.issued | 2003-04-01 | - |
| dc.date.issued | 2018-11-12T13:45:21Z | - |
| dc.identifier | de Erausquin, Gabriel Alejandro; Hyrc, Krzyztof; Dorsey, David A.; Mamah, Daniel; Dokucu, Mehmet; et al.; Nuclear translocation of nuclear transcription factor-κB by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors leads to transcription of p53 and cell death in dopaminergic neurons; American Society for Pharmacology and Experimental Therapeutics; Molecular Pharmacology; 63; 4; 1-4-2003; 784-790 | - |
| dc.identifier | 0026-895X | - |
| dc.identifier | http://hdl.handle.net/11336/67178 | - |
| dc.identifier | 1521-0111 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296119 | - |
| dc.description | We describe a new molecular mechanism of cell death by excitotoxicity mediated through nuclear transcription factor κB (NFκB) in rat embryonic cultures of dopaminergic neurons. Treatment of mesencephalic cultures with α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) resulted in a number of changes that occurred selectively in dopaminergic neurons, including persistent elevation in intracellular Ca2+ monitored with Fura-2, and a significant increase in intramitochondrial oxidation of dihydrorhodamine 123, probably associated with transient increase of mitochondrial permeability, cytochrome c release, nuclear translocation of NFκB, and transcriptional activation of the oncogenep53. Interruption of any of these steps by specific antagonists prevented neurite pruning and programmed cell death. In contrast, cell death was not prevented by caspase antagonists and only partly prevented by nitric-oxide synthase inhibitors. This signal transduction pathway might be a contributing mechanism in ongoing neuronal death in Parkinson disease. | - |
| dc.description | Fil: de Erausquin, Gabriel Alejandro. Washington University School of Medicine; Estados Unidos | - |
| dc.description | Fil: Hyrc, Krzyztof. Washington University School of Medicine; Estados Unidos | - |
| dc.description | Fil: Dorsey, David A.. Washington University School of Medicine; Estados Unidos | - |
| dc.description | Fil: Mamah, Daniel. Washington University School of Medicine; Estados Unidos | - |
| dc.description | Fil: Dokucu, Mehmet. Washington University School of Medicine; Estados Unidos | - |
| dc.description | Fil: Masco, Daniel Hugo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Walton, Timothy. Washington University School of Medicine; Estados Unidos | - |
| dc.description | Fil: Dikranian, Krikor. Washington University School of Medicine; Estados Unidos | - |
| dc.description | Fil: Soriano, Mario. Universidad de Valencia; España | - |
| dc.description | Fil: Garcia Verdugo, José Manuel. Universidad de Valencia; España | - |
| dc.description | Fil: Goldberg, Mark P.. Washington University School of Medicine; Estados Unidos | - |
| dc.description | Fil: Dugan, Laura L.. Washington University School of Medicine; Estados Unidos | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society for Pharmacology and Experimental Therapeutics | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://molpharm.aspetjournals.org/content/63/4/784.long | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1124/mol.63.4.784 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | PARKINSON DISEASE | - |
| dc.subject | NUCLEAR TRANSCRIPTION | - |
| dc.subject | CELL DEATH | - |
| dc.subject | Inmunología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Nuclear translocation of nuclear transcription factor-κB by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors leads to transcription of p53 and cell death in dopaminergic neurons | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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