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dc.creatorHofmeyr, G. J.-
dc.creatorSeuc, A. H.-
dc.creatorBetrán, A. P.-
dc.creatorPurnat, T. D.-
dc.creatorCiganda, Álvaro-
dc.creatorMunjanja, S. P.-
dc.creatorManyame, S.-
dc.creatorSingata, M.-
dc.creatorFawcus, S.-
dc.creatorFrank, K.-
dc.creatorHall, D. R.-
dc.creatorCormick, Gabriela-
dc.creatorRoberts, J. M.-
dc.creatorBergel, Eduardo F.-
dc.creatorDrebit, S.K.-
dc.creatorvon Dadelszen, P.-
dc.creatorBelizan, Jose-
dc.creatorCalcium and Pre-eclampsia Study Group-
dc.date2019-02-13T22:22:32Z-
dc.date2019-02-13T22:22:32Z-
dc.date2015-10-
dc.date2019-02-12T13:33:17Z-
dc.date.accessioned2019-04-29T15:32:37Z-
dc.date.available2019-04-29T15:32:37Z-
dc.date.issued2019-02-13T22:22:32Z-
dc.date.issued2019-02-13T22:22:32Z-
dc.date.issued2015-10-
dc.date.issued2019-02-12T13:33:17Z-
dc.identifierHofmeyr, G. J.; Seuc, A. H.; Betrán, A. P.; Purnat, T. D.; Ciganda, Álvaro; et al.; The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study; Elsevier B.V.; Pregnancy Hypertension; 5; 4; 10-2015; 273-279-
dc.identifier2210-7789-
dc.identifierhttp://hdl.handle.net/11336/70125-
dc.identifier2210-7797-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296150-
dc.descriptionBackground Epidemiological findings suggest that the link between poverty and pre-eclampsia might be dietary calcium deficiency. Calcium supplementation has been associated with a modest reduction in pre-eclampsia, and also in blood pressure (BP). Methods This exploratory sub-study of the WHO Calcium and Pre-eclampsia (CAP) trial aims to determine the effect of 500 mg/day elemental calcium on the blood pressure of non-pregnant women with previous pre-eclampsia. Non-pregnant women with at least one subsequent follow-up trial visit at approximately 12 or 24 weeks after randomization were included. Results Of 836 women randomized by 9 September 2014, 1st visit data were available in 367 women of whom 217 had previously had severe pre-eclampsia, 2nd visit data were available in 201 women. There was an overall trend to reduced BP in the calcium supplementation group (1-2.5 mmHg) although differences were small and not statistically significant. In the subgroup with previous severe pre-eclampsia, the mean diastolic BP change in the calcium group (-2.6 mmHg) was statistically larger than in the placebo group (+0.8 mmHg), (mean difference -3.4, 95% CI -0.4 to -6.4; p = 0.025). The effect of calcium on diastolic BP at 12 weeks was greater than in those with non-severe pre-eclampsia (p = 0.020, ANOVA analysis). Conclusions There is an overall trend to reduced BP but only statistically significant in the diastolic BP of women with previous severe pre-eclampsia. This is consistent with our hypothesis that this group is more sensitive to calcium supplementation, however results need to be interpreted with caution.-
dc.descriptionFil: Hofmeyr, G. J.. University of the Witwatersrand; Sudáfrica-
dc.descriptionFil: Seuc, A. H.. World Health Organization; Suiza-
dc.descriptionFil: Betrán, A. P.. World Health Organization; Suiza-
dc.descriptionFil: Purnat, T. D.. World Health Organization; Dinamarca-
dc.descriptionFil: Ciganda, Álvaro. Instituto de Efectividad Clínica y Sanitaria; Argentina-
dc.descriptionFil: Munjanja, S. P.. University of Zimbabwe; Zimbabue-
dc.descriptionFil: Manyame, S.. University of Zimbabwe; Zimbabue-
dc.descriptionFil: Singata, M.. Fort Hare University; Sudáfrica-
dc.descriptionFil: Fawcus, S.. University of Cape Town; Sudáfrica. Mowbray Maternity Hospital; Sudáfrica-
dc.descriptionFil: Frank, K.. University of the Witwatersrand; Sudáfrica-
dc.descriptionFil: Hall, D. R.. Stellenbosch University; Sudáfrica. Tygerberg Hospital; Sudáfrica-
dc.descriptionFil: Cormick, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina-
dc.descriptionFil: Roberts, J. M.. University of Pittsburgh; Estados Unidos-
dc.descriptionFil: Bergel, Eduardo F.. Instituto de Efectividad Clínica y Sanitaria; Argentina-
dc.descriptionFil: Drebit, S.K.. University of British Columbia; Canadá-
dc.descriptionFil: von Dadelszen, P.. University of British Columbia; Canadá-
dc.descriptionFil: Belizan, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina-
dc.descriptionFil: Calcium and Pre-eclampsia Study Group. No especifica;-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherElsevier B.V.-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.preghy.2015.04.001-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2210778915000227-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectBLOOD PRESSURE-
dc.subjectCALCIUM-
dc.subjectHYPERTENSION-
dc.subjectPREECLAMPSIA-
dc.subjectSUPPLEMENTATION-
dc.subjectMedicina Critica y de Emergencia-
dc.subjectMedicina Clínica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleThe effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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