Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Gonzalez, Claudio D. | - |
| dc.creator | Lee, Myung Shik | - |
| dc.creator | Marchetti, Piero | - |
| dc.creator | Pietropaolo, Massimo | - |
| dc.creator | Towns, Roberto | - |
| dc.creator | Vaccaro, Maria Ines | - |
| dc.creator | Watada, Hirotaka | - |
| dc.creator | Wiley, John W. | - |
| dc.date | 2017-02-20T21:00:37Z | - |
| dc.date | 2017-02-20T21:00:37Z | - |
| dc.date | 2011-01 | - |
| dc.date | 2017-02-15T14:08:45Z | - |
| dc.date.accessioned | 2019-04-29T15:32:48Z | - |
| dc.date.available | 2019-04-29T15:32:48Z | - |
| dc.date.issued | 2017-02-20T21:00:37Z | - |
| dc.date.issued | 2017-02-20T21:00:37Z | - |
| dc.date.issued | 2011-01 | - |
| dc.date.issued | 2017-02-15T14:08:45Z | - |
| dc.identifier | Gonzalez, Claudio D.; Lee, Myung Shik; Marchetti, Piero; Pietropaolo, Massimo; Towns, Roberto; et al.; The emerging role of autophagy in the pathophysiology of diabetes mellitus; Landes Bioscience; Autophagy; 7; 1; 1-2011; 2-11 | - |
| dc.identifier | 1554-8627 | - |
| dc.identifier | http://hdl.handle.net/11336/13194 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296217 | - |
| dc.description | An emerging body of evidence supports a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus. Persistent high concentrations of glucose lead to imbalances in the antioxidant capacity within the cell resulting in oxidative stress-mediated injury in both disorders. An anticipated consequence of impaired autophagy is the accumulation of dysfunctional organelles such as mitochondria within the cell. Mitochondria are the primary site of the production of reactive oxygen species (ROS), and an imbalance in ROS production relative to the cytoprotective action of autophagy may lead to the accumulation of ROS. Impaired mitochondrial function associated with increased ROS levels have been proposed as mechanisms contributing to insulin resistance. In this article we review and interpret the literature that implicates a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus as it applies to β-cell dysfunction, and more broadly to organ systems involved in complications of diabetes including the cardiovascular, renal and nervous systems. | - |
| dc.description | Fil: Gonzalez, Claudio D.. Hospital CEMIC; Argentina. Universidad de Buenos Aires; Argentina | - |
| dc.description | Fil: Lee, Myung Shik. Samsung Medical Center; Corea del Sur | - |
| dc.description | Fil: Marchetti, Piero. Universita Degli Studi Di Pisa; Italia | - |
| dc.description | Fil: Pietropaolo, Massimo. University Of Michigan; Estados Unidos | - |
| dc.description | Fil: Towns, Roberto. University Of Michigan; Estados Unidos | - |
| dc.description | Fil: Vaccaro, Maria Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina | - |
| dc.description | Fil: Watada, Hirotaka. Juntendo University. School of Medicine; Japón | - |
| dc.description | Fil: Wiley, John W.. University Of Michigan; Estados Unidos | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Landes Bioscience | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359481/ | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4161/auto.7.1.13044 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/auto.7.1.13044 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | AUTOPHAGY | - |
| dc.subject | DIABETES MELLITUS | - |
| dc.subject | DIABETES COMPLICATIONS | - |
| dc.subject | OXIDATIVE STRESS | - |
| dc.subject | MITOCHONDRIA DYSFUNCTION | - |
| dc.subject | AUTOIMMUNITY | - |
| dc.subject | Patología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | The emerging role of autophagy in the pathophysiology of diabetes mellitus | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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