Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Gargini, Ricardo | - |
| dc.creator | Cerliani, Juan Pablo | - |
| dc.creator | Escoll, Maribel | - |
| dc.creator | Anton, Ines M. | - |
| dc.creator | Wandosell, Francisco | - |
| dc.date | 2016-03-04T18:12:00Z | - |
| dc.date | 2016-03-04T18:12:00Z | - |
| dc.date | 2015-03 | - |
| dc.date | 2016-03-30 10:35:44.97925-03 | - |
| dc.date.accessioned | 2019-04-29T15:32:48Z | - |
| dc.date.available | 2019-04-29T15:32:48Z | - |
| dc.date.issued | 2016-03-04T18:12:00Z | - |
| dc.date.issued | 2016-03-04T18:12:00Z | - |
| dc.date.issued | 2015-03 | - |
| dc.date.issued | 2016-03-30 10:35:44.97925-03 | - |
| dc.identifier | Gargini, Ricardo; Cerliani, Juan Pablo; Escoll, Maribel; Anton, Ines M.; Wandosell, Francisco; Cancer stem cell-like phenotype and survival are coordinately regulated by Akt/FoxO/Bim pathway; Wiley; Stem Cells; 33; 3; 3-2015; 646-660 | - |
| dc.identifier | 1066-5099 | - |
| dc.identifier | http://hdl.handle.net/11336/4625 | - |
| dc.identifier | 1549-4918 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296220 | - |
| dc.description | Many solid tumors contain a subpopulation of cells with stem characteristics and these are known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). These cells drive tumor growth and appear to be regulated by molecular pathway different from other cells in the tumor bulk. Here, we set out to determine whether elements of the PI3K-AKT pathway are necessary to maintain the CSC-like phenotype in breast tumor cells and for these cells to survive, bearing in mind that the identification of such elements is likely to be relevant to define future therapeutic targets. Our results demonstrate a close relationship between the maintenance of the CSC-like phenotype and the survival of these TICs. Inhibiting PI3K activity, or eliminating AKT activity, mostly that of the AKT1 isoform, produces a clear drop in TICs survival, and a reduction in the generation and growth of CD44(High) /CD24(Low) mammospheres. Surprisingly, the apoptosis of these TICs that is triggered by AKT1 deficiency is also associated with a loss of the stem cell/mesenchymal phenotype and a recovery of epithelial-like markers. Finally, we define downstream effectors that are responsible for controlling the CSC-phenotype, such as FoxO-Bim, and the death of these cells in the absence of AKT1. In summary, these data closely link the maintenance of the stem cell-like phenotype and the survival of these cells to the AKT-FoxO-Bim pathway. | - |
| dc.description | Fil: Gargini, Ricardo. Universidad Autonoma de Madrid. Centro de Biologia Molecular; España | - |
| dc.description | Fil: Cerliani, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina | - |
| dc.description | Fil: Escoll, Maribel. Universidad Autonoma de Madrid. Centro de Biologia Molecular; España. Consejo Superior de Investigaciones Cientificas. Centro Nacional de Biotecnologia; España | - |
| dc.description | Fil: Anton, Ines M.. Consejo Superior de Investigaciones Cientificas. Centro Nacional de Biotecnologia; España. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas; España | - |
| dc.description | Fil: Wandosell, Francisco. Universidad Autonoma de Madrid. Centro de Biologia Molecular; España | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/ark/http://onlinelibrary.wiley.com/doi/10.1002/stem.1904/abstract | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/doi:10.1002/stem.1904 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/issn/1066-5099 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | STEM CELLS | - |
| dc.subject | AKT | - |
| dc.subject | FOXO | - |
| dc.subject | BIM | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.subject | Patología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Cancer stem cell-like phenotype and survival are coordinately regulated by Akt/FoxO/Bim pathway | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.