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dc.provenanceCONICET-
dc.creatorKviatcovsky, Denise-
dc.creatorRivadeneyra, Leonardo-
dc.creatorBalboa, Luciana-
dc.creatorYokobori, Noemí-
dc.creatorLópez, Beatriz-
dc.creatorRitacco, Gloria Viviana-
dc.creatorSchattner, Mirta Ana-
dc.creatorSasiain, María del Carmen-
dc.creatorde la Barrera, Silvia Susana-
dc.date2018-11-26T20:54:46Z-
dc.date2018-11-26T20:54:46Z-
dc.date2017-09-
dc.date2018-10-23T20:26:42Z-
dc.date.accessioned2019-04-29T15:32:52Z-
dc.date.available2019-04-29T15:32:52Z-
dc.date.issued2018-11-26T20:54:46Z-
dc.date.issued2018-11-26T20:54:46Z-
dc.date.issued2017-09-
dc.date.issued2018-10-23T20:26:42Z-
dc.identifierKviatcovsky, Denise; Rivadeneyra, Leonardo; Balboa, Luciana; Yokobori, Noemí; López, Beatriz; et al.; Mycobacterium tuberculosis Multidrug-Resistant Strain M Induces Low IL-8 and Inhibits TNF- α Secretion by Bronchial Epithelial Cells Altering Neutrophil Effector Functions; Hindawi Publishing Corporation; Mediators of Inflammation; 2017; 9-2017; 1-13; 2810606-
dc.identifier0962-9351-
dc.identifierhttp://hdl.handle.net/11336/65234-
dc.identifier1466-1861-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296248-
dc.descriptionM strain, the most prevalent multidrug-resistant strain of Mycobacterium tuberculosis (Mtb) in Argentina, has mounted mechanisms to evade innate immune response. The role of human bronchial epithelium in Mtb infection remains unknown as well as its crosstalk with neutrophils (PMN). In this work, we evaluate whether M and H37Rv strains invade and replicate within bronchial epithelial cell line Calu-6 and how conditioned media (CM) derived from infected cells alter PMN responses. We demonstrated that M infects and survives within Calu-6 without promoting death. CM from M-infected Calu-6 (M-CM) did not attract PMN in correlation with its low IL-8 content compared to H37Rv-CM. Also, PMN activation and ROS production in response to irradiated H37Rv were impaired after treatment with M-CM due to the lack of TNF-α. Interestingly, M-CM increased H37Rv replication in PMN which would allow the spreading of mycobacteria upon PMN death and sustain IL-8 release. Thus, our results indicate that even at low invasion/replication rate within Calu-6, M induces the secretion of factors altering the crosstalk between these nonphagocytic cells and PMN, representing an evasion mechanism developed by M strain to persist in the host. These data provide new insights on the role of bronchial epithelium upon M infection.-
dc.descriptionFil: Kviatcovsky, Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina-
dc.descriptionFil: Rivadeneyra, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina-
dc.descriptionFil: Balboa, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina-
dc.descriptionFil: Yokobori, Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina-
dc.descriptionFil: López, Beatriz. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina-
dc.descriptionFil: Ritacco, Gloria Viviana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina-
dc.descriptionFil: Sasiain, María del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina-
dc.descriptionFil: de la Barrera, Silvia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina-
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dc.languageeng-
dc.publisherHindawi Publishing Corporation-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/mi/2017/2810606/-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2017/2810606-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/23433-
dc.subjectepithelium-
dc.subjectneutrophils-
dc.subjectimmune response-
dc.subjectMycobacterium tuberculosis-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleMycobacterium tuberculosis Multidrug-Resistant Strain M Induces Low IL-8 and Inhibits TNF- α Secretion by Bronchial Epithelial Cells Altering Neutrophil Effector Functions-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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