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dc.provenanceCONICET-
dc.creatorFernández, Gerardo Abel-
dc.creatorMandolesi, Pablo Sergio-
dc.creatorRotstein, Nora Patricia-
dc.creatorColombo, Oscar-
dc.creatorAgamennoni, Osvaldo Enrique-
dc.creatorPoliti, Luis Enrique-
dc.date2016-02-29T19:06:04Z-
dc.date2016-02-29T19:06:04Z-
dc.date2013-12-
dc.date2016-03-30 10:35:44.97925-03-
dc.date.accessioned2019-04-29T15:33:02Z-
dc.date.available2019-04-29T15:33:02Z-
dc.date.issued2013-12-
dc.identifierFernández, Gerardo Abel; Mandolesi, Pablo Sergio; Rotstein, Nora Patricia; Colombo, Oscar; Agamennoni, Osvaldo Enrique; et al.; Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease; Association For Research In Vision And Ophthalmology; Investigative Ophthalmology & Visual Science; 54; 13; 12-2013; 8345-8352-
dc.identifier0146-0404-
dc.identifierhttp://hdl.handle.net/11336/4532-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296316-
dc.descriptionPurpose Eye movements follow a reproducible pattern during normal reading. Each eye movement ends up in a fixation point, which allows the brain to process the incoming information and to program the following saccade. Alzheimer disease (AD) produces eye movement abnormalities and disturbances in reading. In this work we investigated whether eye movement alterations during reading might be already present at very early stages of the disease. Methods Twenty female and male adult patients with the diagnosis of probable AD and 20 age-matching individuals with no evidence of cognitive decline participated in the study. Participants were seated in front of a 20-inch LCD monitor and single sentences were presented on it. Eye movements were recorded with an eyetracker, with a sampling rate of 1000 Hz and an eye position resolution of 20-s arc. Results Analysis of eye movements during reading revealed that patients with early AD decreased the amount of words with only one fixations, increased their total number of first and second pass fixations, the amount of saccade regressions and the number of words skipped, compared with healthy individuals (controls). They also reduced the size of outgoing saccades, simultaneously increasing fixation duration. Conclusions The present study shows that patients with mild AD evidenced marked alterations in eye movement behavior during reading, even at early stages of the disease. Hence, evaluation of eye movement behavior during reading might provide a useful tool for a more precise early diagnosis of AD and for dynamical monitoring of the pathology.-
dc.descriptionFil: Fernández, Gerardo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet - Bahía Blanca. Instituto de Investigación En Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur; Argentina-
dc.descriptionFil: Mandolesi, Pablo Sergio. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina-
dc.descriptionFil: Rotstein, Nora Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina. Universidad Nacional del Sur; Argentina-
dc.descriptionFil: Colombo, Oscar. Hospital Municipal de Agudos, Bahia Blanca; Argentina-
dc.descriptionFil: Agamennoni, Osvaldo Enrique. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina-
dc.descriptionFil: Politi, Luis Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina. Universidad Nacional del Sur; Argentina-
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dc.languageeng-
dc.publisherAssociation For Research In Vision And Ophthalmology-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1167/iovs.13-12877-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/24282223-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1167/iovs.13-12877-
dc.relationinfo:eu-repo/semantics/altIdentifier/ark/http://www.iovs.org/content/early/2013/11/25/iovs.13-12877.abstract?sid=5ca3fa0b-b958-4c69-a27e-a2b20c678254-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/4532-
dc.subjectALZHEIMER DISEASE-
dc.subjectREADING-
dc.subjectEYE TRACKING-
dc.subjectCOGNITIVE IMPAIRMENT-
dc.subjectSACCADIC MOVEMENTS-
dc.subjectEYE FIXATION-
dc.subjectNeurociencias-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleEye Movement Alterations During Reading in Patients With Early Alzheimer Disease-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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