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dc.provenanceCONICET-
dc.creatorHodge, Deborah L.-
dc.creatorReynolds, Della-
dc.creatorCerban, Fabio Marcelo-
dc.creatorCorrea, Silvia Graciela-
dc.creatorBaez, Natalia Soledad-
dc.creatorYoung, Howard A.-
dc.creatorRodriguez Galan, Maria Cecilia-
dc.date2018-08-10T16:38:55Z-
dc.date2018-08-10T16:38:55Z-
dc.date2012-10-
dc.date2018-08-08T18:16:38Z-
dc.date.accessioned2019-04-29T15:33:16Z-
dc.date.available2019-04-29T15:33:16Z-
dc.date.issued2012-10-
dc.identifierHodge, Deborah L.; Reynolds, Della; Cerban, Fabio Marcelo; Correa, Silvia Graciela; Baez, Natalia Soledad; et al.; MCP-1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes; Wiley VCH Verlag; European Journal of Immunology; 42; 10; 10-2012; 2644-2654-
dc.identifier0014-2980-
dc.identifierhttp://hdl.handle.net/11336/54965-
dc.identifier2090-0031-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296411-
dc.descriptionMature lymphocyte immigration into the thymus has been documented in mouse, rat, and pig models, and highly increases when cells acquire an activated phenotype. Entrance of peripheral B and T cells into the thymus has been described in healthy and pathological situations. However, it has not been proposed that leukocyte recirculation to the thymus could be a common feature occurring during the early phase of a Th1 inflammatory/infectious process when a large number of peripheral cells acquire an activated phenotype and the cellularity of the thymus is seriously compromised. The data we present here demonstrate that in well-established Th1 models triggered by different types of immunogens, for example, LPS treatment (a bacterial product), Candida albicans infection (a fungus), and after Trypanosoma cruzi infection (a parasite), a large number of mature peripheral B and T cells enter the thymus. This effect is dependent on, but not exclusive of, the available space in the thymus. Our data also demonstrate that MCP-1/CCR2 (where MCP-1 is monocyte chemoattractant protein-1) interaction is responsible for the infiltration of peripheral cells to the thymus in these Th1-inflammatory/infectious situations. Finally, systemic expression of IL-12 and IL-18 produced during the inflammatory process is ultimately responsible for these migratory events.-
dc.descriptionFil: Hodge, Deborah L.. Center for Cancer Research, Frederick National Laboratory for Cancer Research. Laboratory of Experimental Immunology, Cancer and Inflammation Program; Estados Unidos-
dc.descriptionFil: Reynolds, Della. Center for Cancer Research, Frederick National Laboratory for Cancer Research. Laboratory of Experimental Immunology, Cancer and Inflammation Program; Estados Unidos-
dc.descriptionFil: Cerban, Fabio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina-
dc.descriptionFil: Correa, Silvia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina-
dc.descriptionFil: Baez, Natalia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina-
dc.descriptionFil: Young, Howard A.. Center for Cancer Research, Frederick National Laboratory for Cancer Research. Laboratory of Experimental Immunology, Cancer and Inflammation Program; Estados Unidos-
dc.descriptionFil: Rodriguez Galan, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherWiley VCH Verlag-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201242408-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/eji.201242408-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/54965-
dc.subjectIL-12 AND IL-18-
dc.subjectINFECTION-
dc.subjectMCP-1-
dc.subjectPERIPHERAL B AND T CELLS-
dc.subjectTHYMUS REENTRY-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleMCP-1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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