Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Garcia, Cybele | - |
| dc.creator | Topisirovic, I. | - |
| dc.creator | Djavani, M. | - |
| dc.creator | Borden, K. L. B. | - |
| dc.creator | Damonte, Elsa Beatriz | - |
| dc.creator | Salvato, M. S. | - |
| dc.date | 2018-12-12T20:30:45Z | - |
| dc.date | 2018-12-12T20:30:45Z | - |
| dc.date | 2010-03 | - |
| dc.date | 2018-11-22T16:04:54Z | - |
| dc.date.accessioned | 2019-04-29T15:33:20Z | - |
| dc.date.available | 2019-04-29T15:33:20Z | - |
| dc.date.issued | 2010-03 | - |
| dc.identifier | Garcia, Cybele; Topisirovic, I.; Djavani, M.; Borden, K. L. B.; Damonte, Elsa Beatriz; et al.; An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 393; 4; 3-2010; 625-630 | - |
| dc.identifier | 0006-291X | - |
| dc.identifier | http://hdl.handle.net/11336/66380 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296450 | - |
| dc.description | The promyelocytic leukemia protein (PML) forms nuclear bodies (NB) that can be redistributed by virus infection. In particular, lymphocytic choriomeningitis virus (LCMV) influences disruption of PML NB through the interaction of PML with the arenaviral Z protein. In a previous report, we have shown that the disulfide compound NSC20625 has antiviral and virucidal properties against arenaviruses, inducing unfolding and oligomerization of Z without affecting cellular RING-containing proteins such as the PML. Here, we further studied the effect of the zinc-finger-reactive disulfide NSC20625 on PML-Z interaction. In HepG2 cells infected with LCMV or transiently transfected with Z protein constructs, treatment with NSC20625 restored PML distribution from a diffuse-cytoplasmic pattern to punctate, discrete NB which appeared identical to NB found in control, uninfected cells. Similar results were obtained in cells transfected with a construct expressing a Z mutant in zinc-binding site 2 of the RING domain, confirming that this Z-PML interaction requires the integrity of only one zinc-binding site. Altogether, these results show that the compound NSC20625 suppressed Z-mediated PML NB disruption and may be used as a tool for designing novel antiviral strategies against arenavirus infection. © 2010 Elsevier Inc. All rights reserved. | - |
| dc.description | Fil: Garcia, Cybele. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina | - |
| dc.description | Fil: Topisirovic, I.. University of Montreal; Canadá | - |
| dc.description | Fil: Djavani, M.. University of Maryland; Estados Unidos | - |
| dc.description | Fil: Borden, K. L. B.. University of Montreal; Canadá | - |
| dc.description | Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina | - |
| dc.description | Fil: Salvato, M. S.. University of Maryland; Estados Unidos | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Academic Press Inc Elsevier Science | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0006291X10002512 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.bbrc.2010.02.040 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/66380 | - |
| dc.subject | ANTIVIRAL DISULFIDE AGENT | - |
| dc.subject | ARENAVIRUS | - |
| dc.subject | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | - |
| dc.subject | PROMYELOCYTIC LEUKEMIA PROTEIN | - |
| dc.subject | RING-FINGER INTERACTIONS | - |
| dc.subject | Z PROTEIN | - |
| dc.subject | Salud Ocupacional | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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