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dc.provenanceCONICET-
dc.creatorKunadt, Marcel-
dc.creatorEckermann, Katrin-
dc.creatorStuendl, Anne-
dc.creatorGong, Jing-
dc.creatorRusso, Belisa-
dc.creatorStrauss, Katrin-
dc.creatorRai, Surya-
dc.creatorKügler, Sebastian-
dc.creatorFalomir Lockhart, Lisandro Jorge-
dc.creatorSchwalbe, Martin-
dc.creatorKrumova, Petranka-
dc.creatorOliveira, Luis M. A.-
dc.creatorBähr, Mathias-
dc.creatorMöbius, Wiebke-
dc.creatorLevin, Johannes-
dc.creatorGiese, Armin-
dc.creatorKruse, Niels-
dc.creatorMollenhauer, Brit-
dc.creatorGeiss Friedlander, Ruth-
dc.creatorLudolph, Albert C.-
dc.creatorFreischmidt, Axel-
dc.creatorFeiler, Marisa S.-
dc.creatorDanzer, Karin M.-
dc.creatorZweckstetter, Markus-
dc.creatorJovin, Thomas M.-
dc.creatorSimons, Mikael-
dc.creatorWeishaupt, Jochen H.-
dc.creatorSchneider, Anja-
dc.date2018-07-10T20:31:51Z-
dc.date2018-07-10T20:31:51Z-
dc.date2015-05-
dc.date2018-06-14T19:03:43Z-
dc.date.accessioned2019-04-29T15:33:22Z-
dc.date.available2019-04-29T15:33:22Z-
dc.date.issued2015-05-
dc.identifierKunadt, Marcel; Eckermann, Katrin; Stuendl, Anne; Gong, Jing; Russo, Belisa; et al.; Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation; Springer; Acta Neuropathologica; 129; 5; 5-2015; 695-713-
dc.identifier0001-6322-
dc.identifierhttp://hdl.handle.net/11336/51660-
dc.identifier1432-0533-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296462-
dc.descriptionExtracellular α-Synuclein has been implicated in interneuronal propagation of disease pathology in Parkinson’s Disease. How α-Synuclein is released into the extracellular space is still unclear. Here, we show that α-Synuclein is present in extracellular vesicles in the central nervous system. We find that sorting of α-Synuclein in extracellular vesicles is regulated by sumoylation and that sumoylation acts as a sorting factor for targeting of both, cytosolic and transmembrane proteins, to extracellular vesicles. We provide evidence that the SUMO-dependent sorting utilizes the endosomal sorting complex required for transport (ESCRT) by interaction with phosphoinositols. Ubiquitination of cargo proteins is so far the only known determinant for ESCRT-dependent sorting into the extracellular vesicle pathway. Our study reveals a function of SUMO protein modification as a Ubiquitin-independent ESCRT sorting signal, regulating the extracellular vesicle release of α-Synuclein. We deciphered in detail the molecular mechanism which directs α-Synuclein into extracellular vesicles which is of highest relevance for the understanding of Parkinson’s disease pathogenesis and progression at the molecular level. We furthermore propose that sumo-dependent sorting constitutes a mechanism with more general implications for cell biology.-
dc.descriptionFil: Kunadt, Marcel. Universität Göttingen; Alemania. Nanoscale Microscopy and Molecular Physiology of the Brain; Alemania. Max-Planck-Institute for Experimental Medicine; Alemania-
dc.descriptionFil: Eckermann, Katrin. Nanoscale Microscopy and Molecular Physiology of the Brain; Alemania-
dc.descriptionFil: Stuendl, Anne. Universität Göttingen; Alemania-
dc.descriptionFil: Gong, Jing. Max-Planck-Institute for Experimental Medicine; Alemania-
dc.descriptionFil: Russo, Belisa. Max-Planck-Institute for Experimental Medicine; Alemania-
dc.descriptionFil: Strauss, Katrin. Universität Göttingen; Alemania. Nanoscale Microscopy and Molecular Physiology of the Brain; Alemania-
dc.descriptionFil: Rai, Surya. Universität Göttingen; Alemania-
dc.descriptionFil: Kügler, Sebastian. Nanoscale Microscopy and Molecular Physiology of the Brain; Alemania-
dc.descriptionFil: Falomir Lockhart, Lisandro Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina. Max-Planck-Institute for Biophysical Chemistry; Alemania-
dc.descriptionFil: Schwalbe, Martin. Max-Planck-Institute for Biophysical Chemistry; Alemania-
dc.descriptionFil: Krumova, Petranka. University Medicine Göttingen; Alemania-
dc.descriptionFil: Oliveira, Luis M. A.. Max-Planck-Institute for Biophysical Chemistry; Alemania-
dc.descriptionFil: Bähr, Mathias. Nanoscale Microscopy and Molecular Physiology of the Brain; Alemania-
dc.descriptionFil: Möbius, Wiebke. Nanoscale Microscopy and Molecular Physiology of the Brain; Alemania-
dc.descriptionFil: Levin, Johannes. Ludwig-Maximilians-University; Alemania-
dc.descriptionFil: Giese, Armin. Ludwig-Maximilians-University; Alemania-
dc.descriptionFil: Kruse, Niels. University Medicine Göttingen; Alemania-
dc.descriptionFil: Mollenhauer, Brit. University Medicine Göttingen; Alemania-
dc.descriptionFil: Geiss Friedlander, Ruth. University Medicine Göttingen; Alemania-
dc.descriptionFil: Ludolph, Albert C.. Ulm University; Alemania-
dc.descriptionFil: Freischmidt, Axel. Ulm University; Alemania-
dc.descriptionFil: Feiler, Marisa S.. Ulm University; Alemania-
dc.descriptionFil: Danzer, Karin M.. Ulm University; Alemania-
dc.descriptionFil: Zweckstetter, Markus. Nanoscale Microscopy and Molecular Physiology of the Brain; Alemania-
dc.descriptionFil: Jovin, Thomas M.. Nanoscale Microscopy and Molecular Physiology of the Brain; Alemania-
dc.descriptionFil: Simons, Mikael. Nanoscale Microscopy and Molecular Physiology of the Brain; Alemania-
dc.descriptionFil: Weishaupt, Jochen H.. Nanoscale Microscopy and Molecular Physiology of the Brain; Alemania-
dc.descriptionFil: Schneider, Anja. Universität Göttingen; Alemania. Nanoscale Microscopy and Molecular Physiology of the Brain; Alemania-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherSpringer-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00401-015-1408-1-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/s00401-015-1408-1-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/51660-
dc.subjectEXOSOMES-
dc.subjectSPREADING-
dc.subjectSUMOYLATION-
dc.subjectΑ-SYNUCLEIN-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleExtracellular vesicle sorting of α-Synuclein is regulated by sumoylation-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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