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dc.provenanceCONICET-
dc.creatorMenzel, Stephan-
dc.creatorRissiek, Björn-
dc.creatorHaag, Friedrich-
dc.creatorGoldbaum, Fernando Alberto-
dc.creatorKoch Nolte, Friedrich-
dc.date2017-09-07T14:07:54Z-
dc.date2017-09-07T14:07:54Z-
dc.date2013-08-
dc.date2017-08-29T15:39:32Z-
dc.date.accessioned2019-04-29T15:33:24Z-
dc.date.available2019-04-29T15:33:24Z-
dc.date.issued2013-08-
dc.identifierMenzel, Stephan; Rissiek, Björn; Haag, Friedrich; Goldbaum, Fernando Alberto; Koch Nolte, Friedrich; The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs; Wiley Blackwell Publishing, Inc; Febs Journal; 280; 15; 8-2013; 3543-3550-
dc.identifier1742-464X-
dc.identifierhttp://hdl.handle.net/11336/23753-
dc.identifier1742-4658-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296481-
dc.descriptionIn 1901, the first Nobel Prize in Physiology or Medicine was awarded to Emil von Behring for his ground-breaking discovery of serum therapy: serum from horses vaccinated with toxin-containing culture medium of Corynebacterium diphtheriae contained life-saving 'antitoxins'. The molecular nature of the ADP-ribosylating toxin and the neutralizing antibodies were unraveled only 50 years later. Today, von Behring's antibody therapy is being refined with a new generation of recombinant antibodies and antibody fragments. Nanobodies, which are single-domain antibodies derived from the peculiar heavy-chain antibodies of llamas and other camelids, are emerging as a promising new class of highly specific enzyme inhibitors. In this review, we illustrate the potential of nanobodies as tools to block extracellular and intracellular ADP-ribosyltransferases (ARTs), using the toxin-related membrane-bound mammalian ecto-enzyme ARTC2 and the actin-ADP-ribosylating Salmonella virulence plasmid factor B toxin of Salmonella enterica as examples.-
dc.descriptionFil: Menzel, Stephan. University Medical Center Hamburg-Eppendorf; Alemania-
dc.descriptionFil: Rissiek, Björn. University Medical Center Hamburg-Eppendorf; Alemania-
dc.descriptionFil: Haag, Friedrich. University Medical Center Hamburg-Eppendorf; Alemania-
dc.descriptionFil: Goldbaum, Fernando Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina-
dc.descriptionFil: Koch Nolte, Friedrich. University Medical Center Hamburg-Eppendorf; Alemania-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherWiley Blackwell Publishing, Inc-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/febs.12313-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/febs.12313-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/23753-
dc.subjectnanobodies-
dc.subjectADP-rybosil tranferases-
dc.subjectSalmonella-
dc.subjectBioquímica y Biología Molecular-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleThe art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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