Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Lutzky, Viviana P. | - |
| dc.creator | Carnevale, Romina Paula | - |
| dc.creator | Alvarez, Mariano J. | - |
| dc.creator | Maffia, Paulo Cesar | - |
| dc.creator | Zittermann, Sandra I. | - |
| dc.creator | Podhajcer, Osvaldo Luis | - |
| dc.creator | Issekutz, Andrew C. | - |
| dc.creator | Chuluyan, Hector Eduardo | - |
| dc.date | 2018-07-02T21:21:56Z | - |
| dc.date | 2018-07-02T21:21:56Z | - |
| dc.date | 2006-08 | - |
| dc.date | 2018-06-13T15:11:05Z | - |
| dc.date.accessioned | 2019-04-29T15:33:40Z | - |
| dc.date.available | 2019-04-29T15:33:40Z | - |
| dc.date.issued | 2006-08 | - |
| dc.identifier | Lutzky, Viviana P.; Carnevale, Romina Paula; Alvarez, Mariano J.; Maffia, Paulo Cesar; Zittermann, Sandra I.; et al.; Platelet-endothelial cell adhesion molecule-1 (CD31) recycles and induces cell growth inhibition on human tumor cell lines; Wiley-liss, Div John Wiley & Sons Inc; Journal of Cellular Biochemistry; 98; 5; 8-2006; 1334-1350 | - |
| dc.identifier | 0730-2312 | - |
| dc.identifier | http://hdl.handle.net/11336/50978 | - |
| dc.identifier | 1097-4644 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296561 | - |
| dc.description | CD31 (PECAM-1) is a 130-kDa member of the immunoglobulin gene superfamily expressed on endothelial cells, platelets, and most leukocytes. This report demonstrates by Western Blot and immunofluorescence that some human melanoma and adenocarcinoma cell lines express CD31 on the cell surface. The surface expression of CD31 was regulated by cell-cell contact, being higher on sparse and spontaneously detached cells. Indeed, fixing and permeabilizing tumor cells revealed a cytoplasmic pool, which was confirmed by confocal microscopy. Some of the plasma surface molecule is endocytosed following mAb binding. Engagement of CD31 on tumor cells via domain-3 inhibited proliferation by inducing cell apoptosis. On the other hand, apoptosis does not increase CD31 expression. Overall, these results indicate that there is an intracellular pool of CD31 on some tumor cells, which modulates CD31 surface expression and its role in cancer cell growth and metastasis. Thus, the expression of CD31 and its role in cell survival in some tumor cells appears to differ from endothelial cells. | - |
| dc.description | Fil: Lutzky, Viviana P.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina | - |
| dc.description | Fil: Carnevale, Romina Paula. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Alvarez, Mariano J.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina | - |
| dc.description | Fil: Maffia, Paulo Cesar. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Zittermann, Sandra I.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Dalhousie University Halifax; Canadá | - |
| dc.description | Fil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina | - |
| dc.description | Fil: Issekutz, Andrew C.. Dalhousie University Halifax; Canadá | - |
| dc.description | Fil: Chuluyan, Hector Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley-liss, Div John Wiley & Sons Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.20769 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1002/jcb.20769 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/50978 | - |
| dc.subject | ADENOCARCINOMA | - |
| dc.subject | APOPTOSIS | - |
| dc.subject | CD31 | - |
| dc.subject | CELL GROWTH | - |
| dc.subject | MELANOMA | - |
| dc.subject | PECAM-1 | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Platelet-endothelial cell adhesion molecule-1 (CD31) recycles and induces cell growth inhibition on human tumor cell lines | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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