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dc.provenanceCONICET-
dc.creatorSchillaci, Roxana-
dc.creatorGaleano, Adriana-
dc.creatorBecu, Damasia-
dc.creatorSpinelli, Olga-
dc.creatorSapia, Sandra-
dc.creatorBezares, Raimundo F.-
dc.date2017-12-28T21:00:56Z-
dc.date2017-12-28T21:00:56Z-
dc.date2005-12-
dc.date2017-12-28T13:42:07Z-
dc.date.accessioned2019-04-29T15:34:03Z-
dc.date.available2019-04-29T15:34:03Z-
dc.date.issued2005-12-
dc.identifierBezares, Raimundo F.; Sapia, Sandra; Spinelli, Olga; Becu, Damasia; Galeano, Adriana; Schillaci, Roxana; et al.; Autocrine/paracrine involvement of insulin-like growth factor-I and its receptor in chronic lymphocytic leukemia; Wiley Blackwell Publishing, Inc; British Journal of Haematology; 130; 1; 12-2005; 58-66-
dc.identifier0007-1048-
dc.identifierhttp://hdl.handle.net/11336/31901-
dc.identifier1365-2141-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296711-
dc.descriptionChronic lymphocytic leukaemia (CLL) is characterized by the accumulation of long-lived B lymphocytes blocked in G(0/1) by impaired apoptosis. As insulin-like growth factor-I (IGF-I) is known for its antiapoptotic effects in different cell types, we investigated whether IGF-I and its receptor (IGF-IR) participate in autocrine/paracrine loops affecting the survival of CLL cells. IGF-IR protein and mRNA was present in CLL cells in 44% and 59% of patients respectively. IGF-IR expression in CLL patients was positively correlated with the expression of the antiapoptotic protein Bcl-2 and was involved in CLL cell survival in vitro. Serum IGF-I was elevated in CLL patients, but growth hormone (GH) was normal. CLL cells expressed IGF-I mRNA and secreted the growth factor in vitro. Therefore, local production of IGF-I can account for the increased levels of serum IGF-I, independently of GH, and may be related to autocrine/paracrine control of lymphocyte survival acting at IGF-IR. This is the first demonstration of IGF-IR expression in a subgroup of CLL patients and of its antiapoptotic effects in vitro, highlighting the importance of this growth factor receptor as a possible therapeutic target in CLL.-
dc.descriptionFil: Schillaci, Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina-
dc.descriptionFil: Galeano, Adriana. Sanatorio Mater Dei; Argentina-
dc.descriptionFil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina-
dc.descriptionFil: Spinelli, Olga. Sanatorio Mater Dei; Argentina-
dc.descriptionFil: Sapia, Sandra. Sanatorio Mater Dei; Argentina-
dc.descriptionFil: Bezares, Raimundo F.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherWiley Blackwell Publishing, Inc-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2005.05579.x/full-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1365-2141.2005.05579.x-
dc.relationinfo:eu-repo/semantics/altIdentifier/pmid/15982345-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/31901-
dc.subjectAPOPTOSIS-
dc.subjectINSULINE-LIKE GROWTH FACTOR-
dc.subjectLEUKEMIA-
dc.subjectRECEPTOR IFG TYPE-
dc.subjectTUMOR CELLS-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.subjectPatología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleAutocrine/paracrine involvement of insulin-like growth factor-I and its receptor in chronic lymphocytic leukemia-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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