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| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Frank, Fernanda Maria | - |
| dc.creator | Ulloa, Jerónimo Luis | - |
| dc.creator | Cazorla, Silvia Ines | - |
| dc.creator | Maravilla, G. | - |
| dc.creator | Malchiodi, Emilio Luis | - |
| dc.creator | Grau, A. | - |
| dc.creator | Martino, Virginia Susana | - |
| dc.creator | Catalan, Cesar Atilio Nazareno | - |
| dc.creator | Muschietti, Liliana | - |
| dc.date | 2016-11-08T19:15:46Z | - |
| dc.date | 2016-11-08T19:15:46Z | - |
| dc.date | 2013-06 | - |
| dc.date | 2016-11-07T15:39:34Z | - |
| dc.date.accessioned | 2019-04-29T15:34:03Z | - |
| dc.date.available | 2019-04-29T15:34:03Z | - |
| dc.date.issued | 2013-06 | - |
| dc.identifier | Frank, Fernanda Maria; Ulloa, Jerónimo Luis; Cazorla, Silvia Ines; Maravilla, G.; Malchiodi, Emilio Luis; et al.; Trypanocidal Activity of Smallanthus sonchifolius. Identification of Active Sesquiterpene Lactones by Bioassay-Guided Fractionation.; Oxford University Press; Evidence-based Complementary And Alternative Medicine; 6278; 6-2013; 1-10 | - |
| dc.identifier | 1741-427X | - |
| dc.identifier | http://hdl.handle.net/11336/8064 | - |
| dc.identifier | 1741-4288 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296718 | - |
| dc.description | In order to find novel plant-derived biologically active compounds against Trypanosoma cruzi, we isolated, from the organic extract of Smallanthus sonchifolius, the sesquiterpene lactones enhydrin (1), uvedalin (2), and polymatin B (3) by bioassay-guided fractionation technique. These compounds showed a significant trypanocidal activity against the epimastigote forms of the parasite with IC50 values of 0.84 μM (1), 1.09 μM (2), and 4.90 μM (3). After a 24 h treatment with 10 μg/mL of enhydrin or uvedalin, parasites were not able to recover their replication rate. Compounds 1 and 2 showed IC50 values of 33.4 μM and 25.0 μM against T. cruzi trypomastigotes, while polymatin B was not active. When the three compounds were tested against the intracellular forms of T. cruzi, they were able to inhibit the amastigote replication with IC50 of 5.17 μM, 3.34 μM, and 9.02 μM for 1, 2, and 3, respectively. The cytotoxicity of the compounds was evaluated in Vero cells obtaining CC50 values of 46.5 μM (1), 46.8 μM (2), and 147.3 μM (3) and the selectivity index calculated. According to these results, enhydrin and uvedalin might have potentials as agents against Chagas disease and could serve as lead molecules to develop new drugs. | - |
| dc.description | Fil: Frank, Fernanda Maria. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina | - |
| dc.description | Fil: Ulloa, Jerónimo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina | - |
| dc.description | Fil: Cazorla, Silvia Ines. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina | - |
| dc.description | Fil: Maravilla, G.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina | - |
| dc.description | Fil: Malchiodi, Emilio Luis. Consejo Nacional de Investigaciones Cientiâficas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "profesor R. A. Margni"; Argentina | - |
| dc.description | Fil: Grau, A.. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Instituto de Ecología Regional; Argentina | - |
| dc.description | Fil: Martino, Virginia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina | - |
| dc.description | Fil: Catalan, Cesar Atilio Nazareno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina | - |
| dc.description | Fil: Muschietti, Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco (i); Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Oxford University Press | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ecam/2013/627898/ | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2013/627898 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/8064 | - |
| dc.subject | Chagas disease | - |
| dc.subject | Sesquiterpene lactonas | - |
| dc.subject | Smallanthus sonchifolius | - |
| dc.subject | bioassay-guided fractionation | - |
| dc.subject | Enfermedades Infecciosas | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Trypanocidal Activity of Smallanthus sonchifolius. Identification of Active Sesquiterpene Lactones by Bioassay-Guided Fractionation. | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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