1. RODNA
  2. CONICET
  3. CONICET
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.provenanceCONICET-
dc.creatorMorris Hanon, Olivia-
dc.creatorFurmento, Verónica Alejandra-
dc.creatorRodríguez Varela, Maria Soledad-
dc.creatorMucci, Sofia-
dc.creatorFernandez Espinosa, Damian Dario-
dc.creatorRomorini, Leonardo-
dc.creatorSevlever, Gustavo Emilio-
dc.creatorScassa, Maria Elida-
dc.creatorVidela Richardson, Guillermo Agustín-
dc.date2018-04-05T17:16:15Z-
dc.date2018-04-05T17:16:15Z-
dc.date2017-07-
dc.date2018-04-05T13:42:18Z-
dc.date.accessioned2019-04-29T15:34:28Z-
dc.date.available2019-04-29T15:34:28Z-
dc.date.issued2017-07-
dc.identifierMorris Hanon, Olivia; Furmento, Verónica Alejandra; Rodríguez Varela, Maria Soledad; Mucci, Sofia; Fernandez Espinosa, Damian Dario; et al.; The Cell Cycle Inhibitors p21 Cip1 and p27 Kip1 Control Proliferation but Enhance DNA Damage Resistance of Glioma Stem Cells; Elsevier; Neoplasia; 19; 7; 7-2017; 519-529-
dc.identifier1476-5586-
dc.identifierhttp://hdl.handle.net/11336/40898-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296892-
dc.descriptionHigh-grade gliomas are the most prevalent and lethal primary brain tumors. They display a hierarchical arrangement with a population of self-renewing and highly tumorigenic cells called cancer stemcells. These cells are thought to be responsible for tumor recurrence, which make them main candidates for targeted therapies. Unbridled cell cycle progression may explain the selective sensitivity of some cancer cells to treatments. The members of the Cip/Kip family p21Cip1 and p27Kip1 were initially considered as tumor suppressors based on their ability to block proliferation. However, they are currently looked at as proteins with dual roles in cancer: one as tumor suppressor and the other asoncogene. Therefore, the aimof this study was to determine the functions of these cell cycle inhibitors in five patientderived glioma stem cell?enriched cell lines. We found that these proteins are functional in glioma stem cells. They negatively regulate cell cycle progression both in unstressed conditions and in response to genotoxic stress. In addition, p27Kip1 is upregulated in nutrient-restricted and differentiating cells, suggesting that this Cip/Kip is a mediator of antimitogenic signals in glioma cells. Importantly, the lack of these proteins impairs cell cycle halt in response togenotoxic agents, rendering cells more vulnerable to DNA damage. For these reasons, these proteins may operate both as tumor suppressors, limiting cell proliferation, and as oncogenes, conferring cell resistance to DNA damage.Thus, deepening our knowledge on the biological functions of these Cip/Kipsmay shed light on howsomecancer cells develop drug resistance.-
dc.descriptionFil: Morris Hanon, Olivia. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina-
dc.descriptionFil: Furmento, Verónica Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina-
dc.descriptionFil: Rodríguez Varela, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina-
dc.descriptionFil: Mucci, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina-
dc.descriptionFil: Fernandez Espinosa, Damian Dario. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina-
dc.descriptionFil: Romorini, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina-
dc.descriptionFil: Sevlever, Gustavo Emilio. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina-
dc.descriptionFil: Scassa, Maria Elida. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina-
dc.descriptionFil: Videla Richardson, Guillermo Agustín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherElsevier-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neo.2017.04.001-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458648/-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.neoplasia.com/article/S1476-5586(17)30044-1/fulltext-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.source.urihttp://hdl.handle.net/11336/40898-
dc.subjectGLIOMA STEM CELLS-
dc.subjectDNA DAMAGE-
dc.subjectCELL CYCLE-
dc.subjectCIP/KIP-
dc.subjectInmunología-
dc.subjectMedicina Básica-
dc.subjectCIENCIAS MÉDICAS Y DE LA SALUD-
dc.titleThe Cell Cycle Inhibitors p21 Cip1 and p27 Kip1 Control Proliferation but Enhance DNA Damage Resistance of Glioma Stem Cells-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
Aparece en las colecciones: CONICET

Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro sencillo del ítem