Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.provenance | CONICET | - |
| dc.creator | Poretti, María Belén | - |
| dc.creator | Rask Andersen, Mathias | - |
| dc.creator | Kumar, Praveen | - |
| dc.creator | Rubiales, Susana Elizabeth | - |
| dc.creator | Fiol, Marta Haydee | - |
| dc.creator | Schiöth, Helgi B. | - |
| dc.creator | Carlini, Valeria Paola | - |
| dc.date | 2017-01-17T20:47:31Z | - |
| dc.date | 2017-01-17T20:47:31Z | - |
| dc.date | 2015-01 | - |
| dc.date | 2017-01-13T19:51:02Z | - |
| dc.date.accessioned | 2019-04-29T15:34:32Z | - |
| dc.date.available | 2019-04-29T15:34:32Z | - |
| dc.date.issued | 2015-01 | - |
| dc.identifier | Poretti, María Belén; Rask Andersen, Mathias; Kumar, Praveen; Rubiales, Susana Elizabeth; Fiol, Marta Haydee; et al.; Ghrelin effects expression of several genes associated with depression-like behavior; Elsevier Inc; Progress Of Neuro-psychopharmacology And Biological Psychiatry; 56; 1-2015; 227–234 | - |
| dc.identifier | 0278-5846 | - |
| dc.identifier | http://hdl.handle.net/11336/11510 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/296922 | - |
| dc.description | Ghrelin (Ghr) is an orexigenic peptide that is being investigated for its potential role in development of anxietylike behavior and modulation of depressive-like symptoms induced by bilateral olfactory bulbectomy (OB) in rodents. Olfactory bulbectomy is an animal model useful to study of depression and Ghr could be an alternative therapeutic tool in depression therapy. We studied the effects of intracerebroventricular (i.c.v.) Ghr administration on the expression of hypothalamic genes related to depression and mood (delta opioid receptor (DOR), mu opioid receptor (MOR) and kappa opioid receptor (KOR), lutropin-choriogonadotropic hormone receptor (LHCGR), serotonin transporter (SERT), interleukin 1 beta (IL-1b), vasopressin (AVP) and corticotrophin releasing hormone (CRH)) in OB animals, as well as changes in plasma levels of AVP, CRH and adenocorticotropic hormone (ACTH). We found that acute Ghr 0.3 nmol/μl administration increases gene expression of DOR, SERT and LHCGR in OB mice and decreased expression of IL-1b, suggesting that these genes could be involved in the antidepressant-like effects of Ghr. In addition, OB animals exhibit high AVP gene expression and elevated plasma concentrations of AVP and ACTH and acute Ghr 0.3 nmol/μl administration reduces AVP gene expression and the concentration of these hormones, suggesting that peptide-effects on depressive-like behavior could be mediated at least in part via AVP. In conclusion, this study provides new evidence about genes, receptors and hormones involved in the antidepressant mechanism/s induced by Ghr in OB animals. | - |
| dc.description | Fil: Poretti, María Belén. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina | - |
| dc.description | Fil: Rask Andersen, Mathias. Uppsala University; Suecia | - |
| dc.description | Fil: Kumar, Praveen. Uppsala University; Suecia | - |
| dc.description | Fil: Rubiales, Susana Elizabeth. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas; Argentina | - |
| dc.description | Fil: Fiol, Marta Haydee. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina | - |
| dc.description | Fil: Schiöth, Helgi B.. Uppsala University; Suecia | - |
| dc.description | Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Elsevier Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.pnpbp.2014.09.012 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0278584614001882 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.source.uri | http://hdl.handle.net/11336/11510 | - |
| dc.subject | GHRELIN | - |
| dc.subject | OLFATORY BULBECTOMY | - |
| dc.subject | OPIOID RECEPTORS | - |
| dc.subject | VASOPRESIN | - |
| dc.subject | Fisiología | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Ghrelin effects expression of several genes associated with depression-like behavior | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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