Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Teppa, Roxana Elin | - |
| dc.creator | Zea, Diego Javier | - |
| dc.creator | Marino, Cristina Ester | - |
| dc.date | 2017-11-30T18:43:31Z | - |
| dc.date | 2017-11-30T18:43:31Z | - |
| dc.date | 2017-10 | - |
| dc.date | 2017-11-16T15:09:05Z | - |
| dc.date.accessioned | 2019-04-29T15:34:48Z | - |
| dc.date.available | 2019-04-29T15:34:48Z | - |
| dc.date.issued | 2017-10 | - |
| dc.identifier | Teppa, Roxana Elin; Zea, Diego Javier; Marino, Cristina Ester; Protein-protein interactions leave evolutionary footprints: High molecular coevolution at the core of interfaces; John Wiley & Sons Inc; Protein Science; 26; 12; 10-2017; 2438-2444 | - |
| dc.identifier | 0961-8368 | - |
| dc.identifier | http://hdl.handle.net/11336/29370 | - |
| dc.identifier | 1469-896X | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297048 | - |
| dc.description | Protein-protein interactions are essential to all aspects of life. Specific interactions result from evolutionary pressure at the interacting interfaces of partner proteins. However, evolutionary pressure is not homogeneous within the interface: for instance, each residue does not contribute equally to the binding energy of the complex. To understand functional differences between residues within the interface, we analyzed their properties in the core and rim regions. Here, we characterized protein interfaces with two evolutionary measures, conservation and coevolution, using a comprehensive dataset of 896 protein complexes. These scores can detect different selection pressures at a given position in a multiple sequence alignment. We also analyzed how the number of interactions in which a residue is involved influences those evolutionary signals. We found that the coevolutionary signal is higher in the interface core than in the interface rim region. Additionally, the difference in coevolution between core and rim regions is comparable to the known difference in conservation between those regions. Considering proteins with multiple interactions, we found that conservation and coevolution increase with the number of different interfaces in which a residue is involved, suggesting that more constraints (i.e., a residue that must satisfy a greater number of interactions) allow fewer sequence changes at those positions, resulting in higher conservation and coevolution values. These findings shed light on the evolution of protein interfaces and provide information useful for identifying protein interfaces and predicting protein-protein interactions | - |
| dc.description | Fil: Teppa, Roxana Elin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina | - |
| dc.description | Fil: Zea, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina | - |
| dc.description | Fil: Marino, Cristina Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | text/richtext | - |
| dc.language | eng | - |
| dc.publisher | John Wiley & Sons Inc | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/pro.3318/full | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/pro.3318 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | Coevolution | - |
| dc.subject | Protein-protein interaction | - |
| dc.subject | Evolution | - |
| dc.subject | Protein interface | - |
| dc.subject | Otras Ciencias Biológicas | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Protein-protein interactions leave evolutionary footprints: High molecular coevolution at the core of interfaces | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.