Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Viarengo, Gastón | - |
| dc.creator | Sciara, Mariela Ines | - |
| dc.creator | Salazar, Mario Oscar | - |
| dc.creator | Kieffer, Pablo M. | - |
| dc.creator | Furlan, Ricardo Luis Eugenio | - |
| dc.creator | Garcia Vescovi, Eleonora | - |
| dc.date | 2016-09-06T15:15:08Z | - |
| dc.date | 2016-09-06T15:15:08Z | - |
| dc.date | 2013-06 | - |
| dc.date | 2016-03-16T17:49:43Z | - |
| dc.date.accessioned | 2019-04-29T15:34:50Z | - |
| dc.date.available | 2019-04-29T15:34:50Z | - |
| dc.date.issued | 2016-09-06T15:15:08Z | - |
| dc.date.issued | 2016-09-06T15:15:08Z | - |
| dc.date.issued | 2013-06 | - |
| dc.date.issued | 2016-03-16T17:49:43Z | - |
| dc.identifier | Viarengo, Gastón; Sciara, Mariela Ines; Salazar, Mario Oscar; Kieffer, Pablo M.; Furlan, Ricardo Luis Eugenio; et al.; Unsaturated long-chain free fatty acids are input signals of the Salmonella enterica PhoP/PhoQ regulatory system; American Society for Biochemistry and Molecular Biology; Journal Of Biological Chemistry (online); 288; 6-2013; 22346-22358 | - |
| dc.identifier | 1083-351X | - |
| dc.identifier | http://hdl.handle.net/11336/7467 | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297066 | - |
| dc.description | The Salmonella enterica serovar Typhimurium PhoP/PhoQ system has largely been studied as a paradigmatic two-component regulatory system not only to dissect structural and functional aspects of signal transduction in bacteria but also to gain knowledge about the versatile devices that have evolved allowing a pathogenic bacterium to adjust to or counteract environmental stressful conditions along its life cycle. Mg2+ limitation, acidic pH, and the presence of cationic antimicrobial peptides have been identified as cues that the sensor protein PhoQ can monitor to reprogram Salmonella gene expression to cope with extra- or intracellular challenging conditions. In this work, we show for the first time that long chain unsaturated free fatty acids (LCUFAs) present in Salmonella growth medium are signals specifically detected by PhoQ. We demonstrate that LCUFAs inhibit PhoQ autokinase activity, turning off the expression of the PhoP-dependent regulon. We also show that LCUFAs exert their action independently of their cellular uptake and metabolic utilization by means of the β-oxidative pathway. Our findings put forth the complexity of input signals that can converge to finely tune the activity of the PhoP/PhoQ system. In addition, they provide a new potential biochemical platform for the development of antibacterial strategies to fight against Salmonella infections. | - |
| dc.description | Fil: Viarengo, Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina | - |
| dc.description | Fil: Sciara, Mariela Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina | - |
| dc.description | Fil: Salazar, Mario Oscar. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina | - |
| dc.description | Fil: Kieffer, Pablo M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina | - |
| dc.description | Fil: Furlan, Ricardo Luis Eugenio. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina | - |
| dc.description | Fil: Garcia Vescovi, Eleonora. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Biología Molecular y Celular de Rosario; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | American Society for Biochemistry and Molecular Biology | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/288/31/22346.long | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1074/jbc.M113.472829 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | PhoP/PhoQ | - |
| dc.subject | Salmonella | - |
| dc.subject | unsaturated fatty acids | - |
| dc.subject | natural compounds | - |
| dc.subject | Biología Celular, Microbiología | - |
| dc.subject | Ciencias Biológicas | - |
| dc.subject | CIENCIAS NATURALES Y EXACTAS | - |
| dc.title | Unsaturated long-chain free fatty acids are input signals of the Salmonella enterica PhoP/PhoQ regulatory system | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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