Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Travella, Ana Carolina | - |
| dc.creator | Ripollés, Lorena | - |
| dc.creator | Aventin, Anna | - |
| dc.creator | Rodríguez, Andrea | - |
| dc.creator | Bezares, Raimundo F. | - |
| dc.creator | Caballín, María Rosa | - |
| dc.creator | Slavutsky, Irma Rosa | - |
| dc.date | 2017-07-18T20:01:05Z | - |
| dc.date | 2017-07-18T20:01:05Z | - |
| dc.date | 2013-06 | - |
| dc.date | 2017-07-17T21:14:00Z | - |
| dc.date.accessioned | 2019-04-29T15:34:55Z | - |
| dc.date.available | 2019-04-29T15:34:55Z | - |
| dc.date.issued | 2017-07-18T20:01:05Z | - |
| dc.date.issued | 2017-07-18T20:01:05Z | - |
| dc.date.issued | 2013-06 | - |
| dc.date.issued | 2017-07-17T21:14:00Z | - |
| dc.identifier | Travella, Ana Carolina; Ripollés, Lorena; Aventin, Anna; Rodríguez, Andrea; Bezares, Raimundo F.; et al.; Structural alterations in chronic lymphocytic leukemia: cytogenetic and FISH analysis; Wiley; Hematological Oncology; 31; 2; 6-2013; 339-347 | - |
| dc.identifier | 0278-0232 | - |
| dc.identifier | http://hdl.handle.net/11336/20864 | - |
| dc.identifier | CONICET Digital | - |
| dc.identifier | CONICET | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297097 | - |
| dc.description | In this study, we described cytogenetics and fluorescence in situ hybridization (FISH) analysis performed in chronic lymphocytic leukaemia (CLL) patients with structural alterations. Results were correlated with clinical characteristics. A total of 38 CLL patients: 16 cases with complex and 22 with simple karyotypes were studied. For comparison of clinical parameters, a control group of 78 CLL patients with normal karyotype and without FISH genomic alterations were also evaluated. We found 38 structural abnormalities not previously described in the literature, 28 (74%) of them were translocations. In cases with complex karyotypes, chromosomes 6, 8 and 13 were the most frequently involved in new alterations (nine each), followed by chromosomes 12, 14 and 15 (six each). Chromosome 8p was particularly involved in losses, being 8p21-pter the commonest region of overlap. Cases with simple karyotypes, showed del(6q) as the most frequent alteration (39%). Del(9)(q11) was recurrent in our series. Analysis of clinical parameters showed significant differences in white blood count (p = 0.005) and platelet count (p = 0.015) between patients with structural alterations and the control group. In addition, patients with structural alterations had a significantly shorter time to first treatment (TFT) (29 months) than the control group (69 months) (p = 0.037). Cases with complex karyotypes had a lower proportion of patients in Rai 0 clinical stage (15.4% vs 75%) (p = 0.005) and higher β2 microglobulin levels (3.3 vs 2.5 µg/mL) (p = 0.037) than those with simple karyotypes. Furthermore, a shorter TFT (13 months) and overall survival (56 months) in the complex karyotypes group compared with controls (69 and 144 months, respectively) (p = 0.015 and p = 0.005, respectively) were also found. Our results support the importance of cytogenetic analysis for clinical outcome in CLL and suggest that the diversity of genomic alterations is much greater than previously appreciated. | - |
| dc.description | Fil: Travella, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | - |
| dc.description | Fil: Ripollés, Lorena. Universitat Autònoma de Barcelona; España | - |
| dc.description | Fil: Aventin, Anna. Hospital de Sant Pau; España | - |
| dc.description | Fil: Rodríguez, Andrea. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina | - |
| dc.description | Fil: Bezares, Raimundo F.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; Argentina | - |
| dc.description | Fil: Caballín, María Rosa. Universitat Autònoma de Barcelona; España | - |
| dc.description | Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Wiley | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/hon.2025/abstract | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/hon.2025 | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | CHRONIC LYMPHOCYTIC LEUKAEMIA | - |
| dc.subject | CYTOGENETICS | - |
| dc.subject | FISH | - |
| dc.subject | COMPLEX KARYOTYPES | - |
| dc.subject | Genética Humana | - |
| dc.subject | Medicina Básica | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | Structural alterations in chronic lymphocytic leukemia: cytogenetic and FISH analysis | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
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