Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Coraglia, Ana Carina | - |
| dc.creator | Belmonte, Liliana | - |
| dc.creator | Parodi Ramoneda, Cecilia María | - |
| dc.creator | Baston, Mariela | - |
| dc.creator | Baré, Patricia | - |
| dc.creator | Ruibal Ares, Beatriz | - |
| dc.creator | Galassi, Nora Virginia | - |
| dc.creator | de Bracco, María M. E. | - |
| dc.date | 2017-03-20T17:45:19Z | - |
| dc.date | 2017-03-20T17:45:19Z | - |
| dc.date | 2010-11 | - |
| dc.date | 2017-03-20T14:53:21Z | - |
| dc.date.accessioned | 2019-04-29T15:35:23Z | - |
| dc.date.available | 2019-04-29T15:35:23Z | - |
| dc.date.issued | 2017-03-20T17:45:19Z | - |
| dc.date.issued | 2017-03-20T17:45:19Z | - |
| dc.date.issued | 2010-11 | - |
| dc.date.issued | 2017-03-20T14:53:21Z | - |
| dc.identifier | Coraglia, Ana Carina; Belmonte, Liliana; Parodi Ramoneda, Cecilia María; Baston, Mariela; Baré, Patricia; et al.; B Lymphocyte memory in X-linked Lymphoproliferative disease (XLP); Bentham Science Publishers; Current Immunology Reviews; 6; 4; 11-2010; 323-328 | - |
| dc.identifier | 1573-3955 | - |
| dc.identifier | http://hdl.handle.net/11336/14089 | - |
| dc.identifier | 1875-631X | - |
| dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297292 | - |
| dc.description | X-linked lymphoproliferative disease (XLP) is a severe immunodeficiency characterized by hypogammaglobulinemia, fulminant infectious mononucleosis, and/or lymphoma associated to mutations of the SH2D1A gene, encoding SAP (signaling lymphocytic activation molecule-associated protein). The initial encounter with Epstein Barr virus (EBV) triggers a massive response that leads to a fatal outcome in around 50% of the XLP individuals. Most surviving patients develop hypogammaglobulinemia and eventually B cell lymphoma. B lymphocyte development seems to be normal, but there is a marked reduction of memory B cells (CD27+ B lymphocytes). In addition, Th1 cell mediated immune responses predominate over Th2 responses. Hypogammaglobulinemia and failure to develop a long term humoral immune response can be explained because both the germinal center (GC) reaction and GC formation in secondary lymphoid organs are greatly impaired both in human XLP and in experimental SAP deficiency. Non switched memory B cells (IgM+, IgD+, CD27+ B lymphocytes) persist in XLP patients, suggesting that in spite of the lack of a GC reaction, some subgroups of memory B lymphocytes can play a role in immune homeostasis in these patients. In addition, their persistence in the presence of EBV infection, could perhaps be associated to late occurrence of extranodal B-cell lymphoma, which is another pathological condition associated to the absence of SAP in humans. | - |
| dc.description | Fil: Coraglia, Ana Carina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Belmonte, Liliana. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina | - |
| dc.description | Fil: Parodi Ramoneda, Cecilia María. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Baston, Mariela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina | - |
| dc.description | Fil: Baré, Patricia. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: Ruibal Ares, Beatriz. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina | - |
| dc.description | Fil: Galassi, Nora Virginia. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | - |
| dc.description | Fil: de Bracco, María M. E.. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina | - |
| dc.format | application/pdf | - |
| dc.format | application/msword | - |
| dc.format | application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Bentham Science Publishers | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/1573395511006040323 | - |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/86956/article | - |
| dc.rights | info:eu-repo/semantics/restrictedAccess | - |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
| dc.source | reponame:CONICET Digital (CONICET) | - |
| dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
| dc.source | instacron:CONICET | - |
| dc.subject | B CELL MEMORY | - |
| dc.subject | XLP | - |
| dc.subject | SAP | - |
| dc.subject | HUMORAL RESPONSE | - |
| dc.subject | CD27 | - |
| dc.subject | LONG TERM MEMORY | - |
| dc.subject | Otras Ciencias de la Salud | - |
| dc.subject | Ciencias de la Salud | - |
| dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
| dc.title | B Lymphocyte memory in X-linked Lymphoproliferative disease (XLP) | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.type | info:ar-repo/semantics/articulo | - |
| Aparece en las colecciones: | CONICET | |
Ficheros en este ítem:
No hay ficheros asociados a este ítem.