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dc.creatorBolatti, Elisa Maria-
dc.creatorChouhy, Diego-
dc.creatorHošnjak, Lea-
dc.creatorCasal, Pablo E.-
dc.creatorKocjan, Boštjan J.-
dc.creatorBottai, Hebe-
dc.creatorStella, Emma Julieta-
dc.creatorSanchez, Adriana-
dc.creatorBussy, Ramón Fernandez-
dc.creatorPoljak, Mario-
dc.creatorGiri, Adriana Angelica-
dc.date2018-07-27T18:44:22Z-
dc.date2018-07-27T18:44:22Z-
dc.date2017-06-
dc.date2018-06-26T22:34:52Z-
dc.date.accessioned2019-04-29T15:35:24Z-
dc.date.available2019-04-29T15:35:24Z-
dc.date.issued2018-07-27T18:44:22Z-
dc.date.issued2018-07-27T18:44:22Z-
dc.date.issued2017-06-
dc.date.issued2018-06-26T22:34:52Z-
dc.identifierBolatti, Elisa Maria; Chouhy, Diego; Hošnjak, Lea; Casal, Pablo E.; Kocjan, Boštjan J.; et al.; Natural history of human papillomavirus infection of sun-exposed healthy skin of immunocompetent individuals over three climatic seasons and identification of HPV209, a novel betapapillomavirus; Society for General Microbiology; Journal of General Virology; 98; 6; 6-2017; 1334-1348-
dc.identifier0022-1317-
dc.identifierhttp://hdl.handle.net/11336/53328-
dc.identifierCONICET Digital-
dc.identifierCONICET-
dc.identifier.urihttp://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297301-
dc.descriptionWe present the first longitudinal study reporting the natural history of human papillomavirus (HPV) infection in sun-exposed skin of healthy individuals living in a geographical area in which solar UV radiation is influenced by the ozone content of the atmosphere. During three climatic seasons, skin swab samples were obtained from 78 healthy individuals and the prevalence of cutaneous HPVs was assessed with broad-spectrum FAP and CUT primers and determined at 54, 45 and 47 % in spring, summer and winter, respectively. Frequencies of mixed HPV infections were significantly higher in spring with respect to summer and winter (P=0.02). Seventy-one different HPV types/putative types were identified. While 62 volunteers were HPV-infected in at least one season, 23 had persistent infections. β-PVs (β-1) were the most prevalent and persistent. Age was associated with both the infection status (P=0.01) and the type of HPV infection (no infection, indeterminate/ transient, persistent P=0.02). The molecular/phylogenetic analysis of the newly identified β-PV, officially designated as HPV209, showed that the virus has a typical genomic organization of cutaneous HPVs with five early (E6, E7, E1, E2 and E4) and two late genes (L2 and L1), which clusters to the species β-2. This provides useful data on cutaneous HPV infections in high UV-exposed regions.-
dc.descriptionFil: Bolatti, Elisa Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina-
dc.descriptionFil: Chouhy, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina-
dc.descriptionFil: Hošnjak, Lea. University of Ljubljana; Eslovenia-
dc.descriptionFil: Casal, Pablo E.. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina-
dc.descriptionFil: Kocjan, Boštjan J.. University of Ljubljana; Eslovenia-
dc.descriptionFil: Bottai, Hebe. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina-
dc.descriptionFil: Stella, Emma Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina-
dc.descriptionFil: Sanchez, Adriana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina-
dc.descriptionFil: Bussy, Ramón Fernandez. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina-
dc.descriptionFil: Poljak, Mario. University of Ljubljana; Eslovenia-
dc.descriptionFil: Giri, Adriana Angelica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.formatapplication/pdf-
dc.languageeng-
dc.publisherSociety for General Microbiology-
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1099/jgv.0.000774-
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000774-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/-
dc.sourcereponame:CONICET Digital (CONICET)-
dc.sourceinstname:Consejo Nacional de Investigaciones Científicas y Técnicas-
dc.sourceinstacron:CONICET-
dc.subjectCLIMATIC SEASONS-
dc.subjectHPV209-
dc.subjectHUMAN PAPILLOMAVIRUS INFECTION-
dc.subjectPERSISTENCE-
dc.subjectPREVALENCE-
dc.subjectSUN-EXPOSED HEALTHY SKIN-
dc.subjectOtras Ciencias Biológicas-
dc.subjectCiencias Biológicas-
dc.subjectCIENCIAS NATURALES Y EXACTAS-
dc.titleNatural history of human papillomavirus infection of sun-exposed healthy skin of immunocompetent individuals over three climatic seasons and identification of HPV209, a novel betapapillomavirus-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.typeinfo:ar-repo/semantics/articulo-
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