Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.creator | Sosa, Liliana del Valle | - |
dc.creator | Gutiérrez, Silvina | - |
dc.creator | Petiti, Juan Pablo | - |
dc.creator | Vaca, Alicia Maldré del Valle | - |
dc.creator | de Paul, Ana Lucia | - |
dc.creator | Torres, Alicia Ines | - |
dc.date | 2017-01-18T20:55:22Z | - |
dc.date | 2017-01-18T20:55:22Z | - |
dc.date | 2013-04 | - |
dc.date | 2017-01-13T19:47:41Z | - |
dc.date.accessioned | 2019-04-29T15:35:27Z | - |
dc.date.available | 2019-04-29T15:35:27Z | - |
dc.date.issued | 2017-01-18T20:55:22Z | - |
dc.date.issued | 2017-01-18T20:55:22Z | - |
dc.date.issued | 2013-04 | - |
dc.date.issued | 2017-01-13T19:47:41Z | - |
dc.identifier | Sosa, Liliana del Valle; Gutiérrez, Silvina; Petiti, Juan Pablo; Vaca, Alicia Maldré del Valle; de Paul, Ana Lucia; et al.; Cooperative effect of E2 and FGF2 on lactotroph proliferation triggered by signaling initiated at the plasma membrane; American Physiological Society; American Journal Of Physiology-endocrinology And Metabolism; 305; 1; 4-2013; 45-49 | - |
dc.identifier | 0193-1849 | - |
dc.identifier | http://hdl.handle.net/11336/11602 | - |
dc.identifier | 1522-1555 | - |
dc.identifier.uri | http://rodna.bn.gov.ar:8080/jspui/handle/bnmm/297319 | - |
dc.description | In the present work, we investigated the effect of 17β-estradiol (E2) and basic fibroblast growth factor 2 (FGF2) on the lactotroph cell-proliferative response and the related membrane-initiated signaling pathway. Anterior pituitary mixed-cell cultures of random, cycling 3-mo-old female rats were treated with 10 nM E2, E2 membrane-impermeable conjugated BSA (E2-BSA), PPT (ERα agonist), and DPN (ERβ agonist) alone or combined with FGF2 (10 ng/ml) for 30 min or 4 h. Although our results showed that the uptake of BrdU into the nucleus of lactotrophs was not modified by E2 or FGF2 alone, a significant increase in the lactotroph uptake of BrdU was observed after E2/FGF2 coincubation, with this effect being mimicked by PPT/FGF2. These proliferative effects were blocked by ICI 182,780 or PD-98059. The involvement of membrane ER in the proliferative response of prolactin cells induced by the steroid and FGF2 coincubation was confirmed using E2-BSA, and the association between ERα and FGF receptor was observed after E2/FGF2 treatment by immunoprecipitation. A significant increase in the ERK1/2 expression was noted after E2, E2-BSA, PPT, and FGF2 alone, which was more noticeable after E2-BSA/FGF2, E2/FGF2, or PPT/FGF2 treatments. This study provides evidence that E2 and FGF2 exert a cooperative effect on the lactotroph proliferation principally by signaling initiated at the plasma membrane triggering a genomic effect mediated by MEK/ERK1/2, a common signaling pathway, that finally regulates the lactotroph population, thus contributing to pituitary plasticity. | - |
dc.description | Fil: Sosa, Liliana del Valle. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Centro de Microscopia Electronica; Argentina | - |
dc.description | Fil: Gutiérrez, Silvina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Centro de Microscopia Electronica; Argentina | - |
dc.description | Fil: Petiti, Juan Pablo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Centro de Microscopia Electronica; Argentina | - |
dc.description | Fil: Vaca, Alicia Maldré del Valle. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Centro de Microscopia Electronica; Argentina | - |
dc.description | Fil: de Paul, Ana Lucia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Centro de Microscopia Electronica; Argentina | - |
dc.description | Fil: Torres, Alicia Ines. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Centro de Microscopia Electronica; Argentina | - |
dc.format | application/pdf | - |
dc.format | application/pdf | - |
dc.format | application/pdf | - |
dc.format | application/pdf | - |
dc.format | application/pdf | - |
dc.format | application/pdf | - |
dc.format | application/pdf | - |
dc.format | application/pdf | - |
dc.language | eng | - |
dc.publisher | American Physiological Society | - |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1152/ajpendo.00027.2013 | - |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://ajpendo.physiology.org/content/305/1/E41 | - |
dc.rights | info:eu-repo/semantics/restrictedAccess | - |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | - |
dc.source | reponame:CONICET Digital (CONICET) | - |
dc.source | instname:Consejo Nacional de Investigaciones Científicas y Técnicas | - |
dc.source | instacron:CONICET | - |
dc.subject | 17beta-estradiol | - |
dc.subject | Membrane RE | - |
dc.subject | FGF2 | - |
dc.subject | Lactotroph cells | - |
dc.subject | Otras Ciencias de la Salud | - |
dc.subject | Ciencias de la Salud | - |
dc.subject | CIENCIAS MÉDICAS Y DE LA SALUD | - |
dc.title | Cooperative effect of E2 and FGF2 on lactotroph proliferation triggered by signaling initiated at the plasma membrane | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.type | info:ar-repo/semantics/articulo | - |
Aparece en las colecciones: | CONICET |
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